With the deep integration of artificial intelligence (AI) and education, the traditional medical education model has changed greatly. In view of the current application of AI technology represented by ChatGPT, machine learning in clinical medicine, changes should also be actively sought in the teaching of medical practice course. The reform necessity and research status of medical practice course teaching mode in the context of AI were elaborated from the aspects of teaching methods and effects evaluation in this study. And the reform trend for teaching mode of clinical practice course in the context of AI era from three aspects were discussed, innovation in teaching concepts and methodology, accurate teaching evaluation, and AI thinking training of teachers. This study provides a feasible way for medical colleges to train high-level medical talents to meet the development needs of the times.

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