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HomeArticlesVol 35,2025 No.9Detail

The disease burden of infertility in China from 1992 to 2021 based on an age-period-cohort model

Published on Sep. 26, 2025Total Views: 31 timesTotal Downloads: 10 timesDownloadMobile

Author: HUANG Bingyi 1 ZHAO Qin 1 YAO Libo 1 WANG Manyi 1 ZHAO Qianwen 2

Affiliation: 1. Genetic and Precision Medical Laboratory, The First Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Province, China 2. Department of Laboratory, The First Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Province, China

Keywords: Infertility Burden of disease Prevalence Age-period-cohort model

DOI: 10.12173/j.issn.1004-5511.202407057

Reference: Huang BY, Zhao Q, Yao LB, Wang MY, Zhao QW. The disease burden of infertility in China from 1992 to 2021 based on an age-period-cohort model [J]. Yixue Xinzhi Zazhi, 2025, 35(9): 1041-1047. DOI: 10.12173/j.issn.1004-5511.202407057. [Article in Chinese]

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Abstract

Objective  To analyze the disease burden of infertility in China from 1992 to 2021.

Methods  Data for this study were derived from the 2021 Global Burden of Disease Study. Joinpoint regression model was used to analyze the prevalence and disability-adjusted life-year (DALY) rate of infertility in China and their average annual percentage change (AAPC) to assess the changing trend of the disease. Age-period-cohort models were used to explore age, period, and cohort effects.

Results  From 1992 to 2021, the prevalence of infertility decreased for both men [AAPC=-0.39%, 95%CI (-0.43%, -0.35%)] and women [AAPC=-0.39%, 95%CI (-0.40%, -0.32%)]. The DALY rate also decreased for both men [AAPC=-0.41%, 95%CI (-0.46%, -0.38%)] and women [AAPC= -0.41%, 95%CI (-0.44%, -0.37%)]. Age-effect results showed that the prevalence and DALY rates of infertility in both men and women in China increased first and then decreased with age from 1992 to 2021. Period-effect results showed that the risk of infertility and DALY risk decreased for both men and women in China from 1992 to 2021. Cohort-effect results showed that later birth cohorts had lower risks of infertility and DALYs.

Conclusion  From 1992 to 2021, both the prevalence and DALY rates of infertility in China showed a downward trend, with later birth cohorts exhibiting lower risks. Targeted prevention and treatment efforts for different age groups and the active promotion of assisted reproductive technologies can reduce the burden of infertility in  China.

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