Objective  To explore the influencing factors of mild cognitive impairment (MCI) in hospitalized elderly patients with multiple comorbidities, and to construct a MCI risk prediction model based on machine learning (ML) methods.Methods  The study included elderly patients with multiple comorbidities admitted to the First Affiliated Hospital of Xinjiang Medical University as research subje

Objective  To evaluate the role of novel nanomaterial MN receptor targeted inhibition system (MTIS) in targeting and inhibiting clear cell renal cell carcinoma (ccRCC).Methods  The microprobe MTIS was designed and implemented for use with ccRCC cell lines 786- O and Caki-1. The targeting efficacy of both MTIS and MN was examined through laser scanning confocal microscopy (CLSM). CCK-8 an

Objective  To investigate the association and causal relationship between plasma metabolites and salt sensitive hypertension (SSH) using association analysis and Mendelian randomization (MR).Methods  Based on the baseline survey data from the System Epidemiology Study on Salt Sensitivity of Blood Pressure (EpiSS), 60 participants were selected for untargeted metabolomics and whole-genome

Objective  Using spatial epidemiological methods to explore the spatial distribution characteristics and influencing factors of depression among elderly people in China at the provincial and municipal scales.Methods  Based on the data from the fifth round of China Health and Retirement Longitudinal Study in 2020, ArcGIS Pro was used to analyze the spatial distribution characteristics of

Objective  To investigate the role of neutrophil extracellular traps (NETs) in the pathogenesis of ulcerative colitis (UC).Methods  RNA data from UC patients and normal controls were downloaded from the GEO database to screen for differential expression genes (DEGs), intersecting the screened genes with previously reported NETs-associated genes for functional enrichment assays such as GO