Objective  This study aims to investigate the role and mechanism of regulator of G-protein signaling 14 (RGS14) protein in acute myocardial infarction (AMI).Methods  The RGS14 knockout mice were selected to construct AMI model. The cardiac tissue and serum of mice were collected 24 h after modeling, the degree of inflammatory infiltration in the cardiac tissue was analyzed by immunohisto

Objective  To systematically assess the non-linear and lag effects of daily mean temperature on varicella incidence in Weifang using a distributed lag non-linear model (DLNM). Methods Surveillance data on varicella cases and concurrent meteorological data in the Weifang area from January 2014 to December 2023 were collected. A DLNM was applied to analyze the exposure-response relationship be

Objective To summarize the key evidence in the development of drug treatment strategies for type 2 diabetes mellitus (T2DM), and to provide an evidence-based roadmap for tailoring pharmacological strategies in patients with T2DM. Methods  A systematic search of domestic and foreign databases, relevant guidelines websites, and T2DM guidelines and expert consensus organized by the society was

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Objective  To analyze the clinical epidemiological characteristics of critically ill patients with respiratory failure, utilizing spatial epidemiological methods to investigate the relationship between disease onset and seasonal variations, as well as the impact of meteorological factors. Methods  A retrospective analysis was conducted on the demographic and clinical data of critically i