Objective  To clarify the subtype-specific molecular mechanisms of hy-pertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmogenic cardiomyopathy (ACM) in terms of cellular composition, transcriptional features, and intercellular interactions.Methods  The single-nucleus RNA sequencing (snRNA-seq) data from publicly available human heart tissue samples were integrated

Objective  To explore the network structure of burnout and depressive symptoms among social workers and provide evidence for the construction of a precise symptom management program.Methods  This study used baseline data from the China Social Work Longitudinal Study (CSWLS). The survey included basic information, burnout, and depressive symptoms. Regularized partial correlation network (

Objective  To conduct a target trial emulation (TTE) to explore the effect of regular consumption of "medicine and food homology" (MFH) medicinal plants on activities of daily living (ADL) among the Chinese elderly.Methods  Data were derived from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Participants who entered the cohort in 2008, had normal ADL, and did not regularly c

Standards serve as scientific templates for practitioners, and the scientific rigor of their development process directly impacts the effectiveness of services. Against the backdrop of standardization advancing towards greater scientific integrity, openness, and foundational depth, constructing a methodologically rigorous paradigm for standard development has become one of the forefront issues in

Benign prostatic hyperplasia (BPH) is a common urological disease in middle-aged and elderly men. Its incidence increases continuously with age, which significantly affects patients' quality of life and may even be life-threatening. As population aging intensifies, BPH has become an increasingly prominent public health problem. Existing studies suggest that the occurrence and progression of BPH ar