Diabetic foot ulcers (DFU) is a serious complication of diabetes and the leading cause of non-traumatic amputation or amputation. However, the cure rate of DFU is low, and the life quality of DFU patients is still seriously threatened. This study reported the treatment and nursing process of a patient with DFU complicated with infection in the Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, in order to provide reference for clinical treatment and nursing of DFU.

1.黄仁燕, 王宏飞, 王徐红, 等. 紫朱软膏对糖尿病溃疡小鼠创面炎症反应及上皮-间充质转化的影响 [J]. 陕西中医, 2023, 44(12): 1673-1677. [Huang  RY, Wang HF, Wang XH, et al. Effect of Zizhu Ointment on inflammatory reaction and epithelial mesenchymal transformation of wound in diabetes ulcer mice[J]. Shaanxi Journal of Traditional Chinese Medicine, 2023, 44(12): 1673-1677.] DOI: 10.3969/j.issn.1000-7369.2023.12.002.

2.Rathnayake A, Saboo A, Malabu UH, et al. Lower extremity amputations and long-term outcomes in diabetic foot ulcers: a systematic review[J]. World J Diabetes, 2020, 11(9): 391-399. DOI: 10.4239/wjd.v11.i9.391.

3.田野, 张嘉玥, 李新喜, 等. miRNA-15b-5p对糖尿病足大鼠溃疡愈合的影响及可能机制[J]. 解剖科学进展, 2023, 29(4): 411-414, 418. [Tian Y, Zhang JY, Li XX, et al. Effect and possible mechanism of miRNA-15b-5p on ulcer healing in diabetic foot rats[J]. Progress of Anatomical Sciences, 2023, 29(4): 411-414, 418.] DOI: 10.16695/j.cnki.1006-2947.2023.04.020.

4.Niu XF, Yi JH, Zha GQ, et al. Vacuum sealing drainage as a pre-surgical adjunct in the treatment of complex (open) hand injuries: report of 17 cases[J]. Orthop Traumatol Surg Res, 2017, 103(3): 461-464. DOI: 10.1016/j.otsr.2017.01. 008.

5.Liu J, Hu F, Tang J, et al. Homemade-device-induced negative pressure promotes wound healing more efficiently than VSD-induced positive pressure by regulating inflammation, proliferation and remodeling[J]. Int J Mol Med, 2017, 39(4): 879-888. DOI: 10.3892/ijmm.2017.2919.

6.张英英, 胡迪, 曹圆琦, 等. 个案管理师主导的糖尿病足部溃疡患者照护方案实施[J]. 护理学杂志, 2023, 38(7): 31-34. [Zhang YY, Hu D, Cao YQ, et al. Implementation of care plan for patients with diabetes foot ulcer led by case manager[J]. Journal of Nursing Science, 2023, 38(7): 31-34.] DOI: 10.3870/j.issn.1001-4152. 2023.07.03.

7.孙峰. 综合护理在创面负压封闭引流治疗骨科皮肤软组织缺损中的应用[J]. 当代护士(中旬刊), 2020, 27(6): 46-48. [Sun F. The application of comprehensive nursing in the treatment of orthopedic skin and soft tissue defects with negative pressure sealing and drainage of wounds[J]. Modern Nurse, 2020, 27(6): 46-48.]DOI: 10.19792/j.cnki.1006-6411.2020.17.019.

8.王伟. 注射用头孢哌酮钠舒巴坦钠治疗感染性疾病的临床效果及安全性分析[J]. 中国现代药物应用, 2022, 16(20): 36-40. [Wang W. Analysis of clinical effect and safety of cefoperazone sodium and sulbactam sodium for injection in the treatment of infectious diseases[J]. Chinese Journal of Modern Drug Application, 2022, 16(20): 36-40.] DOI: 10.14164/j.cnki.cn11-5581/r.2022.20.009.

9.Guclu E, Kaya G, Ogutlu A, et al. The effect of cefoperazone sulbactam and piperacillin tazobactam on mortality in Gram-negative nosocomial infections[J]. J Chemother, 2020, 32(3): 118-123. DOI: 10.1080/ 1120009X.2020.1730087.

10.白玉, 邹云霞, 张晨霞, 等. 2型糖尿病患者并发足病及足溃疡加重危险因素分析[J]. 护士进修杂志, 2019, 34(20): 1829-1834. [Bai Y, Zou YX, Zhang CX, et al. Risk factors analysis of foot disease and foot ulcer aggravation in patients with type 2 diabetes mellitus[J]. Journal of Nurses Training, 2019, 34(20): 1829-1834.] DOI: 10.16821/j.cnki.hsjx.2019.20.002.

11.Nelson A, Wright-Hughes A, Backhouse MR, et al. CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England[J]. BMJ Open, 2018, 8(1): e019437. DOI: 10.1136/bmjopen- 2017-019437.

12.Dai J, Jiang C, Chen H, et al. Assessment of the risk factors of multidrug-resistant organism infection in adults with type 1 or type 2 diabetes and diabetic foot ulcer[J]. Can J Diabetes, 2020, 44(4): 342-349. DOI: 10.1016/j.jcjd.2019. 10.009.

13.Xu J, Wang QY, Li W. Autologous platelet-rich gel and continuous vacuum sealing drainage for the treatment of patients with diabetic foot ulcer: study protocol[J]. Medicine (Baltimore), 2019, 98(46): e17928. DOI: 10.1097/MD.0000000000017928.

14.莫嘉敏. 下肢动脉病变和组织微循环状况对伤口负压疗法治疗糖尿病足溃疡的疗效影响研究[D]. 南宁: 广西医科大学, 2020. [Mo JM. The effect of different lower extremity arterial disease and tissue microcirculation on negative pressure therapy for diabetes foot ulcer[D]. Nanning: Guangxi Medical University, 2020.] DOI: 10.27038/d.cnki.ggxyu. 2020.000914.

15.Balasubramanian G, Chockalingam N, Naemi R. A systematic evaluation of cutaneous microcirculation in the foot using post-occlusive reactive hyperemia[J]. Microcirculation, 2021, 28(5): e12692. DOI: 10.1111/micc. 12692.

16.邓磊,黄朋,黄成,等. 强化负压封闭引流方案辅助高压氧治疗老年糖尿病足溃疡43例近期疗效及复发率观察[J]. 安徽医药, 2020, 24(8): 1581-1584. [Deng L, Huang P, Huang C, et al. Influence of intensive VSD regimen combined with hyperbaric oxygen therapy on short-term clinical efficacy and recurrence rate of elderly patients with diabetic foot ulcer[J]. Anhui Medical and Pharmaceutical Journal, 2020, 24(8): 1581-1584.] DOI: 10.3969/j.issn.1009-6469.2020.08.026.

17.胡承浩, 李东宇, 庞宗超, 等. 封闭式负压引流技术治疗糖尿病足对创面组织中TGF-β1及其受体表达的影响研究[J]. 中国修复重建外科杂志, 2018, 32(8): 1061-1065. [Hu CH, Li DY, Pang ZC, et al. Effect of vacuum sealing drainage on expressions of transforming growth factor β1 and its receptor in diabetic foot wound[J]. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(8): 1061-1065.] DOI: 10.7507/1002-1892.201802024.

18.何冰心,顾仕林,金珏安,等. 老年女性糖尿病足溃疡患者的营养不良发生状况及影响因素分析[J]. 中国妇幼保健, 2020, 35(24): 4840-4842. [He  BX, Gu  SL, Jin  JA, et al. Analysis of malnutrition and influencing factors in elderly women with diabetes foot ulcer[J]. Maternal & Child Health Care of China, 2020, 35(24): 4840-4842.] DOI: 10.19829/j.zgfybj.issn.1001-4411. 2020.24.063.

19.Martínez García RM, Fuentes Chacón RM, Lorenzo Mora AM, et al. Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot[J]. Nutr Hosp, 2021, 38(2): 60-63. DOI: 10.20960/nh.03800.

20.Vas PRJ, Edmonds ME, Papanas N. Nutritional supplementation for diabetic foot ulcers: the big challenge[J]. Int J Low Extrem Wounds, 2017, 16(4): 226-229. DOI: 10.1177/1534734617740254.

21.黄丽容,吕丽雪,劳美铃,等. 糖尿病足病人营养风险与其临床预后及生存质量的关系[J]. 护理研究, 2020, 34(18): 3296-3301. [Huang LR, Lyu  LX, Lao ML, et al. Relationship between nutritional risk of patients with diabetic foot and their clinical prognosis and quality of life[J]. Chinese Nursing Research, 2020, 34(18): 3296-3301.] DOI: 10.12102/j.issn.1009-6493.2020.18.020.