Objective　To investigate the association between triglyceride-glucose-body mass index (TyG-BMI) and depressive symptoms in individuals with cardiovascular-kidney-metabolic (CKM) syndrome, and its heterogeneity across different stages.Methods This study utilized data from a survey on comorbidities among adults in rural communities in Yichang of Hubei province, conducted in August 2023. Participant

Nested case-control study (NCCS) is a derived type of traditional case-control study. As an observational research method, it has many advantages and provides an efficient, economic and reliable method for clinical research. This article elaborates on the progress of NCCS and their applications in clinical research from the perspective of clinical epidemiological methodology. The principles, class

Clinical practice guidelines contain substantial diagnostic and therapeutic process knowledge to guide clinical decisions. However, since this knowledge is often expressed in natural language, it is difficult for computers to directly understand and execute, which limits its intelligent application. To address this issue, this study proposes a systematic framework to achieve the computability of g

Objective  To clarify the subtype-specific molecular mechanisms of hy-pertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmogenic cardiomyopathy (ACM) in terms of cellular composition, transcriptional features, and intercellular interactions.Methods  The single-nucleus RNA sequencing (snRNA-seq) data from publicly available human heart tissue samples were integrated

Objective  To explore the network structure of burnout and depressive symptoms among social workers and provide evidence for the construction of a precise symptom management program.Methods  This study used baseline data from the China Social Work Longitudinal Study (CSWLS). The survey included basic information, burnout, and depressive symptoms. Regularized partial correlation network (