Objective  To develop a comprehensive intervention strategy for "comorbidity—co-causes—joint-prevention" of depression and obesity among adolescents, providing strategy and basis for subsequent interventions for the comorbidity of depression and obesity.

Methods  Through a review of past guidelines, literatures and policy documents, and combining with existing effective intervention measures, an intervention strategy framework of "comorbidity—co-causes—joint-prevention" was preliminarily constructed. The Delphi method was employed to conduct two rounds of expert consultation, and the analytic hierarchy process was used to rank the importance of the intervention measures.

Results  The preliminary “comorbidity—co-causes—joint-prevention” intervention strategy framework included 7 intervention concepts and 91 corresponding intervention measures. A total of 14 experts were consulted. After two rounds of expert consultation, the expert positive coefficients were both 100%, the average familiarity coefficients were 0.76 and 0.80 respectively, and the average authority coefficients were 0.85 and 0.90 respectively. The Kendall’s  W coordination coefficients of the intervention concepts in the two rounds were 0.21 and 0.25 respectively, and those of the intervention measures were 0.18 and 0.27 respectively. Items with an average feasibility and importance score ≥ 3.5 and a coefficient of variation ≤ 0.25 were retained. The final "comorbidity—co-causes—joint-prevention" intervention strategy for adolescent depression and obesity includes 7 intervention concepts (controlling sugar intake, reducing sedentary time/increasing sun exposure, reducing screen time, ensuring adequate sleep, providing social support, surveillance and supervision), as well as 63 intervention measures in different dimensions, such as students, parents, schools, and medical institutions.

Conclusion  The developed comprehensive intervention strategy for “comorbidity—co-causes—joint-prevention” of depression and obesity among adolescents is highly scientific and reliable, and provides support for the intervention of the comorbidity of depression and obesity in adolescents, which can promote the physical and mental health development of adolescents.

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