Objective  To systematically synthesize qualitative evidence on the inner experiences and care needs of Chinese breast cancer patients during radiotherapy and chemotherapy.

Methods  A systematic search was conducted in databases including PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, WanFang and Chinese Medical Journal Network for qualitative studies published from inception to July 30, 2025. Study quality was assessed using the JBI critical appaisal checklistfor qualitative research, and results were integrated via Meta-synthesis using the JBI thematic synthesis approach.

Results  A total of 21 studies involving 335 patients were included. The overall quality of the included studies was moderate to high. Five core themes were identified: treatment-induced negative emotional responses; multidimensional physical discomfort; dual burden of economic and psychological stress; individualized symptom coping styles; and diverse support needs.

Conclusion  The inner experiences of Chinese breast cancer patients during radiotherapy and chemotherapy are characterized by specificity in negative emotions, chain effects of physical symptoms, interwoven economic and psychological stressors, differentiated coping styles, and diverse support  needs.

1.Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.

2.徐兵河, 王树森, 江泽飞, 等. 中国晚期乳腺癌维持治疗专家共识[J]. 中华医学杂志, 2018, 98(2): 87-90. [Xu BH, Wang SS, Jiang  ZF, et al. Chinese expert consensus on maintenance therapy for advanced breast cancer[J]. National Medical Journal of China, 2018, 98(2): 87-90.]

3.Cheng KK, Yeung RM. Impact of mood disturbance, sleep disturbance, fatigue and pain among patients receiving cancer therapy[J]. Eur J Cancer Care (Engl), 2013, 22(1): 70-78.

4.胡雁. 循证护理学[M]. 北京: 人民卫生出版社, 2017: 130-134. [Hu  Y. Evidence based nursing[M]. Beijing: People' s Medical Publishing House, 2017: 130-134.]

5.方红,孟爱凤,邾萍,等. 年轻乳腺癌患者化疗期间自我感受负担体验的研究[J]. 护理管理杂志, 2018, 18(4): 278-281. [Fang  H, Meng AF, Zhu P, et al. The experience of self-perceived burden during chemotherapy in young patients with breast cancer[J]. Journal of Nursing Management, 2018, 18(4): 278-281.

6.张尊,陈洁. 妊娠期乳腺癌患者治疗期间心理体验及应对方式的质性研究[J]. 现代临床护理, 2017, 16(6): 40-44. [Zhang  Z, Chen J. A qualitative study on the psychological experience and coping strategies of patients with breast cancer during pregnancy and treatment[J]. Modern Clinical Nursing, 2017, 16(6): 40-44.]

7.查耀蕾,杨凤明,金美四,等. 乳腺癌病人放疗期间症状管理体验的质性研究[J]. 全科护理, 2023, 21(34): 4885-4888. [Zha  YL, Yang FM, Jin MS, et al. Qualitative study on the experience of symptom management in breast cancer patients during radiotherapy[J]. Chinese General Practice Nursing, 2023, 21(34): 4885-4888.]

8.张慧,周郁秋,沈春玲,等. 乳腺癌病人康复期间真实体验的质性研究[J]. 护理管理杂志, 2008, 8(5): 15-18. [Zhang H, Zhou YQ, Shen  CL, et al. A qualitative study on the authentic experience of breast cancer patients during rehabilitation[J]. Nursing Management Journal, 2008, 8(5): 15-18.]

9.贾辛婕,王晴,李琳,等. 乳腺癌患者放化疗期间真实体验的质性研究[J]. 护士进修杂志, 2018, 33(17): 1606-1610. [Jia  XJ, Wang  Q, Li L, et al. A qualitative study on the authentic experience of breast cancer patients during radiochemotherapy[J]. Journal of Nursing, 2018, 33(17): 1606-1610.]

10.何丽,胡露红,褚彦香,等. 乳腺癌患者化疗间歇期症状管理体验及需求的质性研究[J]. 护士进修杂志, 2023, 38(5): 475-479. [He  L, Hu LH, Chu YX, et al. A qualitative study on the experience and needs of symptom management during chemotherapy intermissions in breast cancer patients[J]. Journal of Nursing, 2023, 38(5): 475-479.]

11.李金花,肖风帆,李旭英. 乳腺癌患者化疗期间心理体验与护理需求的质性研究[J]. 当代护士(上旬刊), 2017, (8): 60-62. [Li JH, Xiao FF, Li XY. A qualitative study on the psychological experience and nursing needs of breast cancer patients during chemotherapy[J]. Modern Nurse (First Decade Edition), 2017, (8): 60-62.]

12.李芳,陈晓涵,徐洁慧. 新辅助化疗期间乳腺癌患者心理体验的质性研究[J]. 上海护理, 2022, 22(9): 22-26. [Li F, Chen XH, Xu  JH. Qualitative study on psychological experience of breast cancer patients during neoadjuvant chemotherapy[J]. Shanghai Nursing, 2022, 22(9): 22-26.]

13.付屹鸥,陈偶英,韩露,等. 基于生态系统理论育龄期乳腺癌患者婚姻生活体验的质性研究[J]. 护理学报, 2025, 32(14): 7-12. [Fu  YO, Chen OY, Han L, et al. Qualitative study on marital life experience of reproductive-age women with breast cancer based on ecosystem theory[J]. Journal of Nursing Science, 2025, 32(14): 7-12.]

14.阮君怡,刘城,况艺,等. 年轻女性乳腺癌患者经济毒性应对困境的质性研究[J]. 护士进修杂志, 2024, 39(19): 2036-2040, 2054. [Ruan JY, Liu C, Kuang Y, et al. Qualitative study on the dilemmas of coping with financial toxicity in young women with breast cancer[J]. Journal of Nurses Training, 2024, 39(19): 2036-2040, 2054.]

15.Gao WJ, Zhang Q, Wang D, et al. The role expectations of young women as wives after breast cancer treatment: a qualitative study[J]. Int J Nurs Sci, 2024, 11(3): 366-373.

16.刘悦,阮君怡,顾毓涵,等. 年轻女性乳腺癌患者社会再融合行为体验的质性研究[J]. 护士进修杂志, 2024, 39(23): 2494-2498. [Liu Y, Ruan JY, Gu YH, et al. Qualitative study on the behavioral experience of social reintegration in young female breast cancer patients[J]. Journal of Nurses Training, 2024, 39(23): 2494-2498.]

17.顾毓涵,刘悦,马幼蔓,等. 年轻乳腺癌患者社会角色失调及其原因的质性研究[J]. 军事护理, 2025, 42(6): 36-39. [Gu YH, Liu  Y, Ma YM, et al. Qualitative study on social role imbalance and its causes in young breast cancer patients[J]. Military Nursing, 2025, 42(6): 36-39.]

18.韦艳,雷奕,蓝江玲,等. 农村乳腺癌术后过渡期病人社交赋能困境的质性研究[J]. 全科护理, 2024, 22(2): 204-208. [Wei  Y, Lei Y, Lan JL, et al. Qualitative study on the dilemma of social empowerment in rural patients during the postoperative transition period of breast cancer[J]. Chinese General Practice Nursing, 2024, 22(2): 204-208.]

19.饶贞丽,梁樊,成芳,等. 乳腺癌病人院外团体视觉艺术活动真实体验的质性研究[J]. 循证护理, 2024, 10(1): 158-163. [Rao ZL, Liang F, Cheng F, et al. Qualitative study on the real experience of out-of-hospital group visual art activities in breast cancer patients[J]. Evidence-Based Nursing, 2024, 10(1): 158-163.]

20.李树坪,王雅宁,李艳芳,等. 乳腺癌化疗患者营养教育知信行现状及需求的质性研究[J]. 甘肃医药, 2025, 44(3): 262-267. [Li  SP, Wang YN, Li YF, et al. Qualitative study on the current status and needs of knowledge, attitude and practice (KAP) regarding nutrition education in breast cancer patients undergoing chemotherapy[J]. Gansu Medical Journal, 2025, 44(3): 262-267.]

21.李倩,甄晓伟,赵泽榕. 乳腺癌患者参加新辅助治疗临床试验真实体验的质性研究[J]. 天津护理, 2024, 32(2): 138-142. [Li  Q, Zhen XW, Zhao ZR. Qualitative study on the real experience of breast cancer patients participating in neoadjuvant therapy clinical trials[J]. Tianjin Nursing, 2024, 32(2): 138-142.]

22.李文静,王雅娟. 乳腺癌患者化疗期情绪体验及应对模式的质性研究[J]. 心理月刊, 2024, 19(21): 90-92, 96. [Li WJ, Wang  YJ. Qualitative study on emotional experience and coping patterns of breast cancer patients during chemotherapy[J]. Psychological Monthly, 2024, 19(21): 90-92, 96.]

23.肖星婷,王娴,穆文方,等. 乳腺癌患者化疗所致脱发症状体验的质性研究[J]. 上海护理, 2022, 22(9): 27-31. [Xiao  XT, Wang  X, Mu WF, et al. Qualitative study on the symptom experience of chemotherapy-induced alopecia in breast cancer patients[J]. Shanghai Nursing, 2022, 22(9): 27-31.]

24.汤瑞金,韩静,李晓旭,等. 乳腺癌患者家庭融合调适体验的质性研究及护理启示[J]. 中华护理杂志, 2025, 60(8): 940-946. [Tang  RJ, Han J, Li XX, et al. Qualitative study on the experience of family integration and adaptation in breast cancer patients and its nursing implications[J]. Chinese Journal of Nursing, 2025, 60(8): 940-946.]

25.戈映雪, 刘慧妮, 江鑫, 等. 乳腺癌患者经济毒性体验的纵向质性研究[J]. 心理月刊, 2023, 18(10): 13-16. [Ge YX, Liu HN, Jiang  X, et al. Experiences of economic toxicity among breast cancer patients: a longitudinal qualitative study[J]. Psychological Monthly, 2023, 18(10): 13-16.]

26.DeMiglio L, Murdoch V, Ivison J, et al. Factors influencing psychological wellbeing of early breast cancer patients[J]. Rep Pract Oncol Radiother, 2020, 25(6): 913-918.

27.Green McDonald P, O'Connell M, Lutgendorf SK. Psychoneuroimmunology and cancer: a decade of discovery, paradigm shifts, and methodological innovations[J]. Brain Behav Immun, 2013, 30 Suppl(0): S1-S9.

28.Iddrisu M, Aziato L, Lillian A. Socioeconomic impact of breast cancer on young women in Ghana: a qualitative study[J]. Nurs Open, 2021, 8(1): 29-38.

29.李爱珍,夏胡娜,董明芬,等. 初诊乳腺癌患者心理痛苦状况及其影响因素分析[J]. 医院管理论坛, 2018, 35(6): 29-32. [Li AZ, Xia HN, Dong MF, et al. Analysis of psychological distress and its influencing factors in patients with newly diagnosed breast cancer[J]. Hospital Management Forum, 2018, 35(6): 29-32.]

30.耿文慧,周严红,卢霄蒙,等. 乳腺癌术后放疗患者放射区皮肤温度与放射性皮炎程度的相关性分析[J]. 现代中西医结合杂志, 2023, 32(2): 257-260. [Geng WH, Zhou YH, Lu XM, et al. Correlation analysis between skin temperature in the irradiated area and the degree of radiation dermatitis in breast cancer patients after surgery and radiotherapy[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2023, 32(2): 257-260.]

31.Liu D, Zheng Z, Zhang S, et al. Analysis of risk factors related to acute radiation dermatitis in breast cancer patients during radiotherapy[J]. J Cancer Res Ther, 2022, 18(7): 1903-1909.

32.王扶娟,李海军,周江红. 基于循证护理对乳腺癌患者化疗副作用管理策略研究[J]. 世界最新医学信息文摘(连续型电子期刊), 2024, 24(13): 29-33, 39. [Wang FJ, Li HJ, Zhou JH. Research on management strategies of chemotherapy side effects in breast cancer patients based on evidence-based nursing[J]. World Latest Medicine Information (Continuous Electronic Journal), 2024, 24(13): 29-33, 39.]

33.宋田利,付莉,孙永强. 多柔比星脂质体在乳腺癌化疗中的疗效及对化疗毒副作用的影响[J]. 深圳中西医结合杂志, 2022, 32(18): 81-83. [Song TL, Fu L, Sun YQ. Efficacy of liposomal doxorubicin in breast cancer chemotherapy and its impact on chemotherapy toxic side effects[J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2023, 33(12): 81-83.]

34.孙逸凡,金占丰,杨一令,等. 参麦注射液联合化疗治疗乳腺癌疗效和毒副作用的Meta分析[J]. 毒理学杂志, 2024, 38(4): 286-294, 299. [Sun YF, Jin ZF, Yang YL, et al. Meta-analysis of the efficacy and toxic side effects of Shenmai injection combined with chemotherapy in the treatment of breast cancer[J]. Journal of Toxicology, 2024, 38(4): 286-294, 299.]

35.Katsuragi R, Ozturk CN, Chida K, et al. Updates on breast reconstruction: surgical techniques, challenges, and future directions[J]. World J Oncol, 2024, 15(6): 853-870.

36.Liu YF, Liu JE, Mak YW, et al. Prevalence and predictors of breast cancer-related arm lymphedema over a 10-year period in postoperative breast cancer patients: a cross-sectional study[J]. Eur J Oncol Nurs, 2021, 51: 101909.

37.Klein I, Kalichman L, Chen N. et al. A comprehensive approach to risk factors for upper arm morbidities following breast cancer treatment: a prospective study[J]. BMC Cancer, 2021, 21(1): 1251.

38.沈颖,张静,卜庆云,等. 乳腺癌患者心理痛苦水平及其影响因素的纵向研究[J]. 中国护理管理, 2018, 18(5): 617-622. [Shen Y, Zhang J, Bu QY, et al. A longitudinal study of psychological distress and its related factors in patients with breast cancer[J]. Chinese Nursing Management, 2018, 18(5): 617-622.]

39.Macía P, Barranco M, Gorbeña S, et al. Resilience and coping strategies in relation to mental health outcomes in people with cancer[J]. PLoS One, 2021, 16(5): e0252075.

40.史根芽,蔡英杰,刘宇,等. 配偶陪同下乳腺癌患者疾病应对体验的质性研究[J]. 现代临床护理, 2021, 20(2): 52-57. [Shi GY, Cai YJ, Liu Y, et al. Qualitative study on the disease coping experience of breast cancer patients accompanied by their spouses[J]. Modern Clinical Nurse, 2021, 20(2): 52-57.]

41.赵越,刘均娥.正念疗法在乳腺癌患者心理护理中的应用现状 [J]. 护理管理杂志, 2017, 17(6): 412-414. [Zhao Y, Liu JE. Current application of mindfulness therapy in psychological nursing for breast cancer patients[J]. Nursing Management Journal, 2017, 17(6): 412-414.]

42.朱思悦,桂莉. 青年乳腺癌患者心理护理的研究进展[J]. 解放军护理杂志, 2017, 34(23): 58-60. [Zhu SY, Gui L. Research progress on psychological nursing for young breast cancer patients[J]. Journal of Nursing of the PLA, 2017, 34(23): 58-60.]

43.潘丽雅,孙英杰. 聚焦解决模式对乳腺癌术后化疗患者负性情绪及自我效能的影响研究[J]. 护士进修杂志, 2018, 33(21): 1983-1986. [Pan LY, Sun YJ. The effect of solution-focused mode on negative emotions and self-efficacy of breast cancer patients after surgery and chemotherapy[J]. Journal of Nurses Training, 2018, 33(21): 1983-1986.]

44.边静,孙丽丽,倪同伟,等. 同伴教育对乳腺癌患者生活质量影响的Meta分析[J]. 上海护理, 2020, 20(7): 11-14. [Bian J, Sun LL, Ni TW, et al. Meta-analysis on the impact of peer education on the quality of life of breast cancer patients[J]. Shanghai Nursing, 2020, 20(7): 11-14.]

45.周玲,孔红武. 微信平台延续性护理干预对乳腺癌患者术后心理弹性及病耻感的影响[J]. 中华全科医学, 2019, 17(10): 1773-1776. [Zhou L, Kong HW. Effect of continuous nursing intervention based on WeChat platform on post-operative psychological elasticity and shame of breast cancer patients[J]. Chinese Journal of General Practice, 2019, 17(10): 1773-1776.]

46.沈玉英,盛丽丽,严敏. 基于微信平台的延续性护理干预对乳腺癌患者的影响[J]. 齐鲁护理杂志, 2020, 26(9): 18-22. [Shen YY, Sheng LL, Yan M. Influence of continuous nursing intervention based on WeChat platform on breast cancer patients[J]. Qilu Nursing Magazine, 2020, 26(9): 18-22.]

47.Raupach JC, Hiller JE. Information and support for women following the primary treatment of breast cancer[J]. Health Expect, 2002, 5(4): 289-301.

48.Ikeda M, Tamai N, Kanai H, et al. Effects of the appearance care program for breast cancer patients receiving chemotherapy: a mixed method study[J]. Cancer Rep (Hoboken), 2020, 3(3): e1242.