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Research progress of oncoprotein DEPDC1B

Published on May. 23, 2023Total Views: 856 timesTotal Downloads: 447 timesDownloadMobile

Author: Ze-Ming LI 1 Guo-Jin HUANG 2 Qing-Qing WANG 3

Affiliation: 1. Medical Department, Wuhan Fourth Hospital, Wuhan 430032, China 2. Laboratory of Respiratory Diseases, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Province, China 3. Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Keywords: DEPDC1B DEP domain Rho GAP domain Function Cancer

DOI: 10.12173/j.issn.1004-5511.202211019

Reference: Li ZM, Huang GJ, Wang QQ. Research progress of oncoprotein DEPDC1B[J]. Yixue Xinzhi Zazhi, 2023, 33(5): 366-372. DOI: 10.12173/j.issn.1004-5511.202211019. [Article in Chinese]

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Abstract

DEP domain containing protein 1B (DEPDC1B) is overexpressed in a variety of malignant tissues and cells. As an oncoprotein, it participates in the occurrence and development of many kinds of cancers and regulates different malignant biological forms, including promoting tumor cell invasion, migration, proliferation and inhibiting apoptosis, which is closely related to the function of DEP, Rho GAP and other domains. This paper mainly combines the domain composition of oncoprotein DEPDC1B to explore the relationship between oncoprotein DEPDC1B and the occurrence, development and treatment of cancer, in order to provide a reference basis for further study of the mechanism of DEPDC1B in cancer and potential anticancer therapy.

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References

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