Objective To retrieve, evaluate, and summarize the best evidence for phase Ⅱ exercise rehabilitation in patients with kinesiophobia after percutaneous coronary intervention (PCI) for coronary heart disease (CHD), thereby providing a reference for healthcare professionals to guide patients in implementing phase Ⅱ exercise rehabilitation.

Methods Following the 6S evidence resource model and using a top‑down approach, domestic and international databases, relevant guideline websites, and professional society organizations for guidelines, expert consensuses, evidence summaries, systematic reviews, clinical decisions, and original studies on home‑based exercise rehabilitation for phase Ⅱ cardiac rehabilitation in CHD patients were searched. The search period ranged from the inception of each database to March 2026. The quality of included literature was assessed, evidence extraction and synthesis were performed to integrate the best evidence regarding phase Ⅱ rehabilitation exercise in CHD patients with kinesiophobia after PCI.

Results A total of 16 publications were finally included: 6 guidelines, 1 expert consensus, 2 evidence summaries, 1 systematic review, and 5 RCTs. A total of 35 pieces of best evidence were summarized across 6 domains: organizational management, screening and assessment, exercise prescription, kinesiophobia intervention, safety and monitoring and follow-up management.

Conclusion This study summarizes the best evidence for phase Ⅱ exercise rehabilitation in patients with kinesiophobia after PCI for CHD. It is recommended that healthcare professionals fully consider the clinical context, along with the needs and preferences of patients and their families, when applying this evidence to develop appropriate and individualized exercise rehabilitation plans to promote patient recovery.

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