The national development policy of building an innovation-led country in China places greater demands on high level medical professionals with expertise in both clinical practice and research. However, traditional evidence-based medicine courses for medical undergraduate students often suffer from a “theory-practice gap”. At the same time, medical undergraduates tend to start their research late, show little interest in it, and cannot apply their knowledge in practice, which severely hampers the development of their research and innovation skills. To address this issue, Xiangya School of Medicine, Central South University, has developed Research Methods and Practices of Clinical Research and Evidence-Based Medicine for medical undergraduates. This course adopts a “Five-Dimensional Integration” teaching style, focusing on “Early Intervention, Case-Driven Learning, Problem-Oriented Approach, Data Practice and Interest Guidance”. To take advantage of the “knowledge retention period” following methodology courses for undergraduate clinical medicine majors in the 4th year, the course adopts the classic studies in high-level journals as teaching examples. It leverages a provincial chronic disease data platform (medication for cardiovascular diseases) for progressive, hands-on data practice. An interdisciplinary mentorship pool is created to facilitate two-way student-mentor matching and provide long-term research guidance. The program also has a dynamic “short-term to long-term” evaluation system, including process-based evaluation, summative assessment of learning results, and a follow-up evaluation of students' research ability 2-3 years after college. Practice results show that this course effectively stimulates students’ interest in scientific research and helps students formulate scientific questions and solve problems from data. Students taking the optional course have published 4 SCI-indexed papers as the first author or co-author, including publications in top-tier journals such as the European Heart Journal. This paper summarizes the implementation path, innovative measures and preliminary effects of curriculum revision, aiming to provide reference practical experience for the early and systematic cultivation of scientific research and innovation competence in medical undergraduates in China.

1. 教育部, 国家卫生健康委员会, 国家中医药管理局. 关于加强医教协同实施卓越医生教育培养计划2.0的意见[EB/OL]. (2018-10-17) [2026-01-30]. http://www.moe.gov.cn/srcsite/A08/moe_740/s7952/201810/t20181017_351901.html

2. 国务院办公厅. 关于加快医学教育创新发展的指导意见[EB/ OL]. (2020-09-23) [2026-01-30]. http://www.moe.gov.cn/jyb_xxgk/moe_1777/moe_1778/202009/t20200923_490164.html

3. 中共中央, 国务院. 教育强国建设规划纲要(2024—2035年) [EB/ OL]. (2025-01-19) [2026-01-30]. http://www.moe.gov.cn/jyb_xxgk/moe_1777/moe_1778/202501/t20250119_1176193.html

4. 徐浩杰, 王璐, 刘明娟, 等. 三种学制医学研究生科研训练与临床实践现状分析[J]. 协和医学杂志, 2022, 13(1): 66-73. [Xu  HJ, Wang L, Liu MJ, et al. Analysis of the current status of scientific research training and clinical practice among medical postgraduates with three different educational systems[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(1): 66-73.]

5. 马美娟, 黄晓燕, 王沙, 等. 临床专业学位硕士研究生科研能力培养问题探讨[J]. 亚洲急诊医学病例研究, 2024, 12(3): 71-75. [Ma MJ, Huang XY, Wang S, et al. Discussion on the cultivation of scientific research ability of professional degree postgraduates in clinical medicine[J]. Asian Case Reports in Emergency Medicine, 2024, 12(3): 71-75.]

6. 教育部临床医学专业认证工作委员会. 中国本科医学教育标准——临床医学专业(2022版)[M]. 北京: 北京大学医学出版社, 2023.

7. 徐嘉悦, 王雨宁, 孙鑫, 等. 信息时代下的循证医学课程改革探索[J]. 中国循证医学杂志, 2024, 24(5): 612-616. [Xu JY, Wang  YN, Sun X, et al. Exploration of evidence-based medicine curriculum reform in the information age[J]. Chinese Journal of Evidence-Based Medicine, 2024, 24(5): 612-616.]

8. 曹淑江, 唐骏瑶, 顾嘉頠. 创新创业训练计划能否选拔出具备科研能力的本科生——基于某“双一流”高校的实证分析 [J]. 创新与创业教育, 2025, 16(1): 1-11. [Cao SJ, Tang JY, Gu  JW. Can the innovation and entrepreneurship training program select undergraduates with scientific research ability: an empirical analysis based on a "Double First-Class" university[J]. Journal of Innovation and Enterprise Education, 2025, 16(1): 1-11.]

9. 毛宇扬, 张馨月, 黄诗月, 等. 医学本科生“科研前置”培养模式的探索与思考[J]. 华西医学, 2025, 40(11): 1849-1853. [Mao  YY, Zhang XY, Huang SY, et al. Exploration and reflection on the "research-first" training model for medical undergraduates[J]. West China Medical Journal, 2025, 40(11): 1849-1853.]

10. 修晓琳, 薛乔丹, 侯越, 等. 新医科视域下医学生科研训练的现状调查与对策研究[J]. 医学教育管理, 2024, 10(z1): 180-184. [Xiu XL, Xue QD, Hou Y, et al. Investigation and countermeasures of medical students' scientific research training from the perspective of new medical science[J]. Medical Education Management, 2024, 10(z1): 180-184.]

11. 申奥琪, 甘勇, 冯晶, 等. 我国循证医学教学改革研究的文献计量分析[J]. 医学与社会, 2026, 39(1): 23-29, 37. [Shen AQ, Gan  Y, Feng  J, et al. Bibliometric analysis of evidence-based medical teaching reform research in China[J]. Medicine and Society, 2026, 39(1): 23-29, 37.]

12. 刘剑波, 卢建平. 中国循证医学教学研究进展及现状分析[J]. 广西医学, 2024, 46(12): 1969-1972. [Liu JB, Lu JP. Progress and current status analysis of evidence-based medicine teaching research in China[J]. Guangxi Medical Journal, 2024, 46(12): 1969-1972.]

13. 郝卓文, 王颖, 李景峰. 循证医学教学模式在临床教学中的应用[J]. 数理医药学杂志, 2025, 38(10): 793-799. [Hao ZW, Wang  Y, Li  JF. Application of evidence-based medicine teaching model in clinical teaching[J]. Journal of Mathematical Medicine, 2025, 38(10): 793-799.]

14. 王云云, 王宇, 黄笛, 等. 循证医学课程体系的建设与实践——以武汉大学为例[J]. 医学新知, 2022, 32(1): 74-80. [Wang YY, Wang Y, Huang D, et al. Construction and practice of evidence-based medicine curriculum system: a case study of Wuhan university[J]. Yixue Xinzhi Zazhi, 2022, 32(1): 74-80.]

15. 张君佩, 张红云, 刘欣羽, 等. 基于临床流行病学与循证医学的内科规培教学改革实践与效果评估[J]. 职业教育发展, 2026, 15(3): 86-91. [Zhang JP, Zhang HY, Liu XY, et al. Practice and effect evaluation of internal medicine residency teaching reform based on clinical epidemiology and evidence-based medicine[J]. Vocational Education Development, 2026, 15(3): 86-91.]

16. 庞元捷, 刘佳琪, 廖春晓, 等. 新医科背景下医学统计学教学实践与探索[J]. 中华流行病学杂志, 2026, 47(1): 161-166. [Pang YJ, Liu JQ, Liao CX, et al. Teaching practice and exploration of medical statistics under the background of new medical science[J]. Chinese Journal of Epidemiology, 2026, 47(1): 161-166.]

17. 阎思宇, 靳英辉, 王宇, 等. 循证医学类课程对医学研究生批判性思维能力的培养效果[J]. 中华医学教育杂志, 2024, 44(3): 217-221. [Yan SY, Jin YH, Wang Y, et al. Effect of evidence-based medicine courses on cultivating critical thinking ability of medical postgraduates[J]. Chinese Journal of Medical Education, 2024, 44(3): 217-221.]

18. 陈耀龙, 孙雅佳, 罗旭飞, 等. 循证医学的核心方法与主要模型[J]. 协和医学杂志, 2023, 14(1): 1-8. [Chen YL, Sun YJ, Luo XF, et al. Core methods and main models of evidence-based medicine[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 1-8.]

19. 吴晶晶, 卫彬. 基于循证医学PICOS模式的CBL教学法在血液科临床教学中的应用[J]. 检验医学与临床, 2024, 21(6): 862-864. [Wu JJ, Wei B. Application of CBL teaching method based on evidence-based medicine PICOS model in hematology clinical teaching[J]. Laboratory Medicine and Clinic, 2024, 21(6): 862-864.]

20. Yehualashet DE, Seboka BT, Mamo TT, et al. Perspective chapter: evidence-based medicine - a new approach for medical education and practice[M]. Education and Human Development, London: IntechOpen, 2023.

21. Huang TL, Zhou S, Wei QY, et al. Team-, case-, lecture- and evidence-based learning in medical postgraduates training[J]. BMC Medical Education, 2024, 24: 675.

22. 毕晓娟, 李娜, 马晶. PBL教学法在循证医学教学中的应用效果评价[J]. 中国卫生产业, 2024, 21(22): 212-215. [Bi XJ, Li N, Ma J. Evaluation of the application effect of PBL teaching method in evidence-based medicine teaching[J]. China Health Industry, 2024, 21(22): 212-215.]

23. 方超, 陈周, 马雪, 等. 案例+循证医学结合式教学法在抗高血压药理学教学中的应用[J]. 心脏杂志, 2025, 37(1): 110-113, 117. [Fang C, Chen Z, Ma X, et al. Application of case-based and evidence-based medicine combined teaching method in antihypertensive pharmacology teaching[J]. Chinese Heart Journal, 2025, 37(1): 110-113, 117.]

24. 任燕, 李静, 魏万强, 等. 以提升临床研究能力为导向的《临床科研设计》教学创新探讨与效果评价[J]. 中国循证医学杂志, 2025, 25(2): 234-238. [Ren Y, Li J, Wei WQ, et al. Discussion and effect evaluation of teaching innovation of "Clinical Research Design" oriented to improving clinical research ability[J]. Chinese Journal of Evidence-Based Medicine, 2025, 25(2): 234-238.]

25. 袁筱婕, 张维璐, 付婷, 等. “新医科”背景下“循证医学”教学改革探索[J]. 医学教育研究与实践, 2024, 32(4): 462-467. [Yuan  XJ, Zhang WL, Fu T, et al. Exploration of "Evidence-based Medicine" teaching reform under the background of "New Medicine"[J]. Medical Education Research and Practice, 2024, 32(4): 462-467.]

26. 李静, 李娜, 许建雄. 混合式教学在高校课程中的教学改革实践与探索[J]. 创新教育研究, 2025, 13(5): 373-380. [Li J, Li N, Xu  JX. Practice and exploration of blended teaching reform in university courses[J]. Creative Education Studies, 2025, 13(5): 373-380.]

27. 易祯, 吴美玉. 从“混合”到“融合”: 线上线下融合式教学设计研究[J]. 中国教育信息化, 2023, 29(11): 84-96. [Yi Z, Wu  MY. From "blending" to "integration": research on online and offline integrated teaching design[J]. China Education Info, 2023, 29(11): 84-96.]

28. 孙渝莉, 刘瑞. 国内高校混合式教学研究综述[J]. 重庆交通大学学报(社会科学版), 2022, 22(4): 96-103. [Sun YL, Liu R. Review of blended teaching research in domestic universities[J]. Journal of Chongqing Jiaotong University (Social Sciences Edition), 2022, 22(4): 96-103.]

29. 李丽, 李旭蕊, 刘宇. 混合教学模式下多维度形成性评价在制药工程专业人才培养的探索与实践[J]. 职业教育发展, 2024, 13(2): 493-498. [Li L, Li XR, Liu Y. Exploration and practice of multi-dimensional formative evaluation in talent cultivation of pharmaceutical engineering under blended teaching mode[J]. Vocational Education Development, 2024, 13(2): 493-498.]

30. 刘海霞, 王玖, 胡乃宝, 等. 基于SPOC的混合式教学设计与实践: 以医学统计学课程教学为例[J]. 中华医学教育探索杂志, 2023, 22(3): 393-397. [Liu HX, Wang J, Hu NB, et al. Design and practice of blended teaching based on SPOC: taking the teaching of medical statistics course as an example[J]. Chinese Journal of Medical Education Research, 2023, 22(3): 393-397.]

31. 王云云, 袁帅, 王宇, 等. 布鲁姆教育目标分类理论在本科生《循证医学》教学中的应用效果[J]. 医学新知, 2024, 34(10): 1183-1190. [Wang YY, Yuan S, Wang Y, et al. The effect of applying Bloom's taxonomy theory of education in the teaching of evidencebased medicine curriculum for undergraduates[J]. Yixue Xinzhi Zazhi, 2024, 34(10): 1183-1190.]

32. 王鹏, 陶莎莎, 何义胜, 等. 基于认知—行为融合视角的“临床流行病与循证医学”课程教学效果评价与优化策略探讨[J]. 医学新知, 2025, 35(11): 1373-1379. [Wang P, Tao SS, He YS, et al. Evaluation of teaching effect and discussion on optimization strategy of "Clinical Epidemiology and Evidence-Based Medicine" course from cognitive-behavioral integration perspective[J]. Yixue Xinzhi Zazhi, 2025, 35(11): 1373-1379.]

33. 钟荣霞, 楼依玲, 蒋青青, 等. 循证医学课程对临床医学本科生循证实践能力的培养效果评估[J]. 数理医药学杂志, 2025, 38(7): 558-565. [Zhong RX, Lou YL, Jiang QQ, et al. Evaluation of the effect of evidence-based medicine course on cultivating evidence-based practice ability of clinical medical undergraduates[J]. Journal of Mathematical Medicine, 2025, 38(7): 558-565.]

34. Pereza N, Hauser G, Jovanović P. Editorial: the importance of faculty development in medical education[J]. Front Genet, 2026, 17: 1798159.

35. Huang X, Shi T, Hu L, et al. Association between fluid input and mortality in patients with acute right ventricular myocardial infarction[J].

36. J Cardiovasc Aging, 2026, 6: 9.

37. Chen Y, Weng C, Wu J, et al. Clinical characteristics and prognosis differences between isolated right and left ventricular myocardial infarction in the Chinese population: a retrospective study[J]. PeerJ, 2023, 11: e14959.

38. Wang J, Huang P, Yu Q, et al. Epilepsy and long-term risk of arrhythmias[J]. Eur Heart J, 2023, 44(35): 3374-3382.

39. Meng C, Deng P, Miao R, et al. Gut microbiome and risk of ischaemic stroke: a comprehensive Mendelian randomization study[J]. Eur J Prev Cardiol, 2023, 30(7): 613-620.