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HomeArticlesVol 33,2023 No.4Detail

Research progress of long non-coding RNA and miRNA in pathogenesis of preeclamp-sia

Published on Aug. 25, 2023Total Views: 6076 timesTotal Downloads: 2026 timesDownloadMobile

Author: Ying LI 1 Jian WANG 1 Xiu-Feng GU 1 Yu-Ming LI 2 Jin-Peng HU 2

Affiliation: 1. Department of Cardiology, Tianjin Fourth Central Hospital, Tianjin 300140, China 2. Research Department of Characteristic Medical Center of PAP, Tianjin 300162, China

Keywords: Preeclampsia Long non-coding RNA MicroRNA

DOI: 10.12173/j.issn.1004-5511.202111063

Reference: Li Y, Wang J, Gu XF, Li YM, Hu JP. Research progress of long non-coding RNA and miRNA in pathogenesis of preeclampsia[J]. Yixue Xinzhi Zazhi, 2023, 33(4): 280-284. DOI: 10.12173/j.issn.1004-5511.202111063.[Article in Chinese]

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Abstract

Preeclampsia (PE) is a vascular disease characterized by hypertension and proteinuria during pregnancy and is one of the leading causes of maternal and fetal mortality. The placenta plays a central role in the pathogenesis of PE, but the mechanism of its occurrence has not been elucidated. Non-coding RNAs have numerous functions, and it has been shown that long non-coding RNA (lncRNA) and microRNA (miRNA) can in-fluence the development and progression of PE by affecting placental trophoblast cell function. To this end, this study reviews the research progress of lncRNA and miRNA in the pathogenesis of PE, and provides a reference for the prevention and treatment of PE.

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References

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