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HomeArticlesVol 30,2020 No.3Detail

The importance of bismuth-containing quadruple therapy in Helicobacter pylori eradication in an era of increasing antibiotic resistance

Published on Jun. 21, 2020Total Views: 25655 timesTotal Downloads: 5819 timesDownloadMobile

Author: Yi HU 1 Yuan ZHUANG 2 Nong-Hua LYU 1*

Affiliation: 1. Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nan-chang 330006, P.R. China 2. Department of Microbiology and Biochemical Pharmacy, National Engineering Research Center for Immunological Products, School of Pharmacy, Army Medical University, Chongqing 400038, P.R. China

Keywords: Helicobacter pylori Antibiotic resistance Bismuth Efficacy

DOI: 10.12173/j.issn.1004-5511.2020.03.06

Reference: Hu Y, Zhuang Y, Lyu NH. The importance of bismuth-containing quadruple therapy in Helicobacter pylori eradication in an era of increasing antibiotic resistance[J]. Yixue Xinzhi Zazhi, 2020, 30(3): 179-183. DOI: 10.12173/j.issn.1004-5511.2020.03.06.[Article in Chinese]

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Abstract

Approximately half of the global population is infected with Helicobacter pylori (Hp). Currently, the main challenge in the field of Hp is that the antibiotic resistance of Hp is increased, leading to the decreased efficacy of regimens. The prevalence of Hp primary resistance to clarithromycin, metronidazole, and levofloxacin is above the alarming level in most areas of the world. Moreover, Hp was defined as a high-priority bacterium in the World Health Organization (WHO) priority list of antibiotic-resistant bacteria. Bismuth has several advantages, including low resistance rate, safe and improving the eradication rate in Hp resistant strains. Therefore, bismuth-containing quadruple therapy is recommended as the first-line regimens by the international Hp consensus report. This article emphasizes the importance of bismuth-containing quadruple therapy in Hp eradication in an era of increasing antibiotic resistance through reviewing the recently published Hp consensus report and relevant clinical articles.

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