Objective To analyze the influencing factors of in-hospital major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in elderly patients with acute ST-segment elevation myocardial infarction (STEMI) based on multimodal clinical data, to establish a predictive model, and to evaluate the predictive performance of the model.Methods Elderly STEMI patients who underwent

Systematic reviews and Meta-analyses of prognostic factor studies are critical for synthesizing evidence on disease prognostic factors and informing clinical decision-making. However, their methodological quality varies widely, and existing generic quality assessment tools fail to adequately cover the specific methodological features of this type of research. In response, an international team rec

Objective To investigate the association between air pollutant exposure and outpatient visit risk for community-acquired pneumonia (CAP) among children and adolescents, and to further evaluate its lagged effects and seasonal characteristics.Methods Clinical data from children and adolescents diagnosed with CAP at the First People's Hospital of Tianmen between 2021 and 2024 were collected, along wi

Objective To construct chimeric antigen receptor T (CAR-T) cells targeting multiple myeloma-specific antigen-1 (MMSA-1) and evaluate their antitumor activity and preliminary safety in multiple myeloma (MM).Methods Flow cytometry was used to detect MMSA-1/ZDHHC9 expression in K562 cells, MM cell lines (MM.1S, U266, and RPMI-8226), and primary MM cells. MMSA-1-specific single-chain variable fragment

Disabled elderly and people with disabilities are particularly vulnerable to falls and related injuries during toileting, which has become a major public health concern. Currently, systematic and practical consensus guidelines for comprehensive prevention of toileting-related falls remain lacking in China. Based on international and domestic evidence on fall prevention, lower urinary tract symptom