Objective  To evaluate the influencing factors on the diagnostic accuracy of percutaneous peripheral lung lesion biopsy guided by contrast-enhanced ultrasound (CEUS).

Methods  A retrospective analysis was conducted on the clinical data of patients who underwent CEUS-guided percutaneous biopsy for peripheral lung lesions at the Chongqing University Cancer Hospital from January 2020 to March 2024. Patients were divided into a consistent diagnosis group and a inconsistent diagnosis group based on the consistency between the biopsy results and the surgical pathology or clinical follow-up diagnosis. Univariate and multivariate Logistic regression analyses were used to analyze the influencing factors on diagnostic accuracy.

Results  A total of 343 patients who underwent CEUS-guided percutaneous biopsy were included. 294 patients were in the consistent diagnosis group, and 49 patients were in the inconsistent diagnosis group, with a diagnostic accuracy rate of 85.71%. Multivariate Logistic regression analysis showed that lesion size, CEUS enhancement degree, puncture position, and lesion location were independent influencing factors on diagnostic accuracy.

Conclusion  CEUS-guided percutaneous lung biopsy has high diagnostic accuracy and a low complication rate. Its diagnostic results are influenced by both lesion characteristics and operational factors.

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