Neonatal sepsis (NS) is one of the critical diseases in the neonatal period, with a high incidence rate and mortality. Blood culture serves as the gold standard for diagnosing NS, but it takes a long time and has a low positive rate. Therefore, finding more efficient biomarker for early diagnosis and guiding antibiotic treatment is extremely important for improving the prognosis of NS. This article reviews the current research status of biomarker related to routine laboratory indicators, cytokines, cell surface antigens, and metagenomic sequencing, to provide assistance for the early diagnosis of NS.

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