Spinal cord injury (SCI) is a disease that profoundly impacts the central nervous system, with oxidative stress playing a crucial role in its secondary damage. This article provides a comprehensive review of the role of oxidative stress in SCI, its primary signaling pathways, and current treatment methods. It focuses particularly on the functions of pathways such as Nrf-2, PI3K/AKT, and TLR4/MyD88 in the regulation of oxidative stress and explores the potential of antioxidant therapies in alleviating SCI symptoms. This paper aims to offer insights for a deeper understanding of SCI and provide reference for optimizing treatment strategies.

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