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Correlation study of neutrophils in knee osteoarthritis

Published on Mar. 29, 2024Total Views: 456 timesTotal Downloads: 263 timesDownloadMobile

Author: LIU Xin 1 GUO Jiajun 1 MA Hong'e 1 ZHANG Wenxian 2

Affiliation: 1. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China 2. Department of Geriatric Orthopedics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China

Keywords: Knee osteoarthritis Neutrophils MicroRNAs Exosomes Treatment

DOI: 10.12173/j.issn.1004-5511.202310057

Reference: Liu X, Guo JJ, Ma HE, Zhang XW. Correlation study of neutrophils in knee osteoarthritis[J]. Yixue Xinzhi Zazhi, 2024, 34(3): 347-354. DOI: 10.12173/j.issn.1004-5511.202310057.[Article in Chinese]

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Knee osteoarthritis (KOA), as a chronic disability disease that seriously damages the quality of life, will degrade articular cartilage and lead to subchondral bone remodeling, resulting in knee pain, stiffness and limited function. It is one of the most common bone and joint diseases. As an inflammatory disease, the etiology of KOA involves both repair and degradation mechanisms. Neutrophils, as powerful natural immune effector cells that can precisely regulate the function of blood and tissue. It is the first immune cells to enter the synovial membrane after joint injury and is an important factor in joint inflammation and cartilage destruction, and its activity is necessary for the progression of KOA. This article focus on KOA influencing factors, its relationship with neutrophils and macrophages, and the pathological mechanisms of KOA, so as to providing reference for KOA treatment.

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