Welcome to visit Zhongnan Medical Journal Press Series journal website!

Benign prostatic hyperplasia and periodontitis

Published on Mar. 29, 2024Total Views: 1003 timesTotal Downloads: 630 timesDownloadMobile

Author: YANG Shisong 1, 2 ZHU Cong 2, 3 QIAN Xinhang 1, 2 HOU Junqing 4, 5 FANG Cheng 2

Affiliation: 1. School of Clinical Medicine, Henan University, Kaifeng 475400, Henan Province, China 2. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 3. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 4. Department of Urology, Kaifeng 155 Hospital, China Rong Tong Medical Healthcare Group Co. Ltd., Kaifeng 475400, Henan Province, China 5. Henan Engineering Research Center of Prostate Disease Prevention and Diagnosis, Kaifeng 475400, Henan Province, China

Keywords: Benign prostatic hyperplasia Periodontitis Inflammation Oxidative stress

DOI: 10.12173/j.issn.1004-5511.202402025

Reference: Yang SS, Zhu C, Qian XH, Hou JQ, Fang C. Benign prostatic hyperplasia and periodontitis[J]. Yixue Xinzhi Zazhi, 2024, 34(3): 330-338. DOI: 10.12173/j.issn.1004-5511.202402025.[Article in Chinese]

  • Abstract
  • Full-text
  • References
Abstract

Benign prostatic hyperplasia and periodontitis are common chronic diseases in middle-aged and elderly people, with many common risk factors and pathogenesis. Epidemiological studies have found that periodontitis can increase the risk of prostate hyperplasia, however, its mechanism is not clear yet. This article reviews the current research status and possible mechanisms of the correlation between periodontitis and benign prostatic hyperplasia, aiming to provide a basis and ideas for future clinical diagnosis, treatment, and related research.

Full-text
Please download the PDF version to read the full text: download
References

1.Williams DW, Greenwell-Wild T, Brenchley L, et al. Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity[J]. Cell, 2021, 184(15): 4090-4104. e15. DOI: 10.1016/j.cell.2021.05.013.

2.Peres MA, Macpherson LMD, Weyant RJ, et al. Oral diseases: a global public health challenge[J]. Lancet, 2019, 394(10194): 249-260. DOI: 10.1016/s0140-6736(19)31146-8.

3.Miernik A, Gratzke C. Current treatment for benign prostatic hyperplasia[J]. Dtsch Arztebl Int, 2020, 117(49): 843-854. DOI: 10.3238/arztebl.2020.0843.

4.Loe H, Theilade E, Jensen SB. Experimental gingivitis in man[J]. J Periodontol (1930), 1965, 36: 177-187. DOI: 10.1902/jop.1965.36.3.177.

5.Theilade E. The non-specific theory in microbial etiology of inflammatory periodontal diseases[J]. J Clin Periodontol, 1986, 13(10): 905-911. DOI: 10.1111/j.1600-051x.1986.tb01425.x.

6.Marsh PD. Sugar, fluoride, pH and microbial homeostasis in dental plaque[J]. Proc Finn Dent Soc, 1991, 87(4): 515-525. https://pubmed.ncbi.nlm.nih.gov/1775479/.

7.Socransky SS, Haffajee AD, Cugini MA, et al. Microbial complexes in subgingival plaque[J]. J Clin Periodontol, 1998, 25(2): 134-144. DOI: 10.1111/j.1600-051x.1998.tb02419.x.

8.Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets[J]. Periodontol 2000, 2002, 28: 12-55. DOI: 10.1034/j.1600-0757.2002.280102.x.

9.Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis, unlearning learned concepts[J]. Periodontol 2000, 2013, 62(1): 203-217. DOI: 10.1111/j.1600-0757.2012.00450.x.

10.Abdulkareem AA, Al-Taweel FB, Al-Sharqi AJB, et al. Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis[J]. J Oral Microbiol, 2023, 15(1): 2197779. DOI: 10.1080/20002297.2023.2197779.

11.Chigasaki O, Aoyama N, Sasaki Y, et al. Porphyromonas gingivalis, the most influential pathogen in red-complex bacteria: a cross-sectional study on the relationship between bacterial count and clinical periodontal status in Japan[J]. J Periodontol, 2021, 92(12): 1719-1729. DOI: 10.1002/jper.21-0011.

12.Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities[J]. Nat Rev Immunol, 2021, 21(7): 426-440. DOI: 10.1038/s41577-020-00488-6.

13.Chughtai B, Forde JC, Thomas DD, et al. Benign prostatic hyperplasia[J]. Nat Rev Dis Primers, 2016, 2: 16031. DOI: 10.1038/nrdp.2016.31.

14.Devlin CM, Simms MS, Maitland NJ. Benign prostatic hyperplasia-what do we know?[J]. BJU Int, 2021, 127(4): 389-399. DOI: 10.1111/bju.15229.

15.赖良海, 赵伟, 肖云新, 等. 1 470 nm激光"平均三分法"剜除术与等离子剜除术治疗前列腺增生的比较[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(3): 252-256. [Lai LH, Zhao W, Xiao YX, et al. A comparative study of 1 470 nm laser "mean trichotomy" enucleation of the prostate and transurethral plasmakinetic enucleation for benign prostatic hyperplasia[J]. Chinese Journal of Endourology (Electronic Edition), 2023, 17(3): 252-256. ] DOI: 10.3877/cma.j.issn.1674-3253.2023.03.011.

16.Joshi N, Bissada NF, Bodner D, et al. Association between periodontal disease and prostate-specific antigen levels in chronic prostatitis patients[J]. J Periodontol, 2010, 81(6): 864-869. DOI: 10.1902/jop.2010.090646.

17.Mao M, Zhu H, Xie Y, et al. Correlation between periodontitis and prostate-specific antigen levels in the elderly Chinese male population[J]. BMC Oral Health, 2022, 22(1): 163. DOI: 10.1186/s12903-022-02171-9.

18.Huang Y, Michaud DS, Lu J, et al. The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: the 2009-2010 National Health and Nutrition Examination Survey[J]. Cancer Causes Control, 2019, 30(12): 1293-1300. DOI: 10.1007/s10552-019-01238-3.

19.Kruck S, Hennenlotter J, Amend B, et al. Chronic periodontitis does not impact serum levels of prostate-specific antigen[J]. Anticancer Res, 2017, 37(6): 3163-3167. DOI: 10.21873/anticanres.11675.

20.Ortíz De Urbina Comerón P, Zubizarreta-Macho Á, Lobo Galindo AB, et al. Relationship between prostate inflammation and periodontal disease-a systematic review and .Meta-analysis[J]. J Clin Med, 2023, 12(18): 6070. DOI: 10.3390/jcm12186070.

21.Boland MR, Hripcsak G, Albers DJ, et al. Discovering medical conditions associated with periodontitis using linked electronic health records[J]. J Clin Periodontol, 2013, 40(5): 474-482. DOI: 10.1111/jcpe.12086.

22.Estemalik J, Demko C, Bissada NF, et al. Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases[J]. J Periodontol, 2017, 88(9): 823-829. DOI: 10.1902/jop.2017.160477.

23.Wu L, Li BH, Wang YY, et al. Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study[J]. Mil Med Res, 2019, 6(1): 34. DOI: 10.1186/s40779-019-0223-8.

24.Fu E, Cheng CM, Chung CH, et al. Association of chronic periodontitis with prostatic hyperplasia and prostatitis: a population-based cohort study in Taiwan[J]. J Periodontol, 2021, 92(1): 72-86. DOI: 10.1002/jper.19-0706.

25.Hyun H, Park YW, Kwon YC, et al. Relationship between chronic periodontitis and lower urinary tract symptoms/benign prostatic hyperplasia[J]. Int Neurourol J, 2021, 25(1): 77-83. DOI: 10.5213/inj.2040072.036.

26.Alluri LSC, Paes Batista Da Silva A, Verma S, et al. Presence of specific periodontal pathogens in prostate gland diagnosed with chronic inflammation and adenocarcinoma[J]. Cureus, 2021, 13(9): e17742. DOI: 10.7759/cureus.17742.

27.Fang C, Wu L, Zhao MJ, et al. Periodontitis exacerbates benign prostatic hyperplasia through regulation of oxidative stress and inflammation[J]. Oxid Med Cell Longev, 2021, 2021: 2094665. DOI: 10.1155/2021/2094665.

28.Guo XP, Yang J, Wu L, et al. Periodontitis relates to benign prostatic hyperplasia via the gut microbiota and fecal metabolome[J]. Front Microbiol, 2023, 14: 1280628. DOI: 10.3389/fmicb.2023.1280628.

29.Kim DH, Jeong SN, Lee JH. Chronic periodontal disease increases risk for prostate cancer in elderly individuals in South Korea: a retrospective nationwide population-based cohort study[J]. J Cancer, 2020, 11(16): 4716-4723. DOI: 10.7150/jca.45369.

30.Vignozzi L, Rastrelli G, Corona G, et al. Benign prostatic hyperplasia: a new metabolic disease?[J]. J Endocrinol Invest, 2014, 37(4): 313-322. DOI: 10.1007/s40618-014-0051-3.

31.Bregaint S, Boyer E, Fong SB, et al. Porphyromonas gingivalis outside the oral cavity[J]. Odontology, 2022, 110(1): 1-19. DOI: 10.1007/s10266-021-00647-8.

32.Chen Y, Wang H, Yang Q, et al. Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis[J]. Theranostics, 2022, 12(3): 1074-1096. DOI: 10.7150/thno.65694.

33.Kim WJ, Park SY, Kim OS, et al. Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts[J]. J Periodontol, 2022, 93(3): 380-391. DOI: 10.1002/jper.21-0178.

34.Liu D, Li M, Fu X, et al. Changes in the expression and functional activities of C-X-C motif chemokine ligand 13 (CXCL13) in hyperplastic prostate[J]. Int J Mol Sci, 2022, 24(1): 56. DOI: 10.3390/ijms24010056.

35.Kim BH, Kim CI, Chang HS, et al. Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia: is it related to apoptosis and angiogenesis of prostate cancer?[J]. Korean J Urol, 2011, 52(4): 253-259. DOI: 10.4111/kju.2011.52.4.253.

36.Wolff JM, Stephenson RN, Chisholm GD, et al. Levels of circulating intercellular adhesion molecule-1 in patients with metastatic cancer of the prostate and benign prostatic hyperplasia[J]. Eur J Cancer, 1995, 31A(3): 339-341. DOI: 10.1016/0959-8049(94)00446-c.

37.De Nunzio C, Presicce F, Tubaro A. Inflammatory mediators in the development and progression of benign prostatic hyperplasia[J]. Nat Rev Urol, 2016, 13(10): 613-626. DOI: 10.1038/nrurol.2016.168.

38.Dong C, Zhang NJ, Zhang LJ. Oxidative stress in leukemia and antioxidant treatment[J]. Chin Med J (Engl), 2021, 134(16): 1897-1907. DOI: 10.1097/cm9. 0000000000001628.

39.Yamaguchi T, Yamamoto Y, Egashira K, et al. Oxidative stress inhibits endotoxin tolerance and may affect periodontitis[J]. J Dent Res, 2023, 102(3): 331-339. DOI: 10.1177/00220345221138523.

40.Novaković N, Cakić S, Todorović T, et al. Antioxidative status of saliva before and after non-surgical periodontal treatment[J]. Srp Arh Celok Lek, 2013, 141(3-4): 163-168. DOI: 10.2298/sarh1304163n.

41.Almerich-Silla JM, Montiel-Company JM, Pastor S, et al. Oxidative stress parameters in saliva and its association with periodontal disease and types of bacteria[J]. Dis Markers, 2015, 2015: 653537. DOI: 10.1155/2015/653537.

42.Minciullo PL, Inferrera A, Navarra M, et al. Oxidative stress in benign prostatic hyperplasia: a systematic review[J]. Urol Int, 2015, 94(3): 249-254. DOI: 10.1159/000366210.

43.Zhao MJ, Yuan S, Zi H, et al. Oxidative stress links aging-associated cardiovascular diseases and prostatic diseases[J]. Oxid Med Cell Longev, 2021, 2021: 5896136. DOI: 10.1155/2021/5896136.

44.Roumeguère T, Sfeir J, El Rassy E, et al. Oxidative stress and prostatic diseases[J]. Mol Clin Oncol, 2017, 7(5): 723-728. DOI: 10.3892/mco.2017.1413.

45.Merendino RA, Salvo F, Saija A, et al. Malondialdehyde in benign prostate hypertrophy: a useful marker?[J]. Mediators Inflamm, 2003, 12(2): 127-128. DOI: 10. 1080/0962935031000097745.

46.Vital P, Castro P, Ittmann M. Oxidative stress promotes benign prostatic hyperplasia[J]. Prostate, 2016, 76(1): 58-67. DOI: 10.1002/pros.23100.

47.Zeze T, Shinjo T, Sato K, et al. Endothelial insulin resistance exacerbates experimental periodontitis[J]. J Dent Res, 2023, 102(10): 1152-1161. DOI: 10.1177/00220345231181539.

48.Chen Z, Miao L, Gao X, et al. Effect of obesity and hyperglycemia on benign prostatic hyperplasia in elderly patients with newly diagnosed type 2 diabetes[J]. Int J Clin Exp Med, 2015, 8(7): 11289-11294. https://pubmed.ncbi.nlm.nih.gov/26379937/.

49.Nandeesha H, Koner BC, Dorairajan LN, et al. Hyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia[J]. Clin Chim Acta, 2006, 370(1-2): 89-93. DOI: 10.1016/j.cca.2006.01.019.

50.Song E, Park MJ, Kim JA, et al. Implication of thyroid function in periodontitis: a nationwide population-based study[J]. Sci Rep, 2021, 11(1): 22127. DOI: 10.1038/s41598-021-01682-9.

51.Eldhose A, Nandeesha H, Dorairajan LN, et al. Thyroid and parathyroid hormones in benign prostatic hyperplasia[J]. Br J Biomed Sci, 2016, 73(2): 94-96. DOI: 10.1080/09674845.2016.1173333.

52.Xiong Y, Zhang F, Wu C, et al. The circadian syndrome predicts lower urinary tract symptoms suggestive of benign prostatic hyperplasia better than metabolic syndrome in aging males: a 4-year follow-up study [J]. Front Med (Lausanne), 2021, 8: 715830. DOI: 10.3389/fmed.2021.715830.

53.Virto L, Cano P, Jiménez-Ortega V, et al. Melatonin as adjunctive therapy in the treatment of periodontitis associated with obesity[J]. J Clin Periodontol, 2018, 45(11): 1336-1346. DOI: 10.1111/jcpe.13013.

54.Liu RY, Li L, Zhang ZT, et al. Clinical efficacy of melatonin as adjunctive therapy to non-surgical treatment of periodontitis: a systematic review and Meta-analysis[J]. Inflammopharmacology, 2022, 30(3): 695-704. DOI: 10.1007/s10787-022-00959-3.

55.Obayashi K, Saeki K, Kurumatani N. Association between melatonin secretion and nocturia in elderly individuals: a cross-sectional study of the HEIJO-KYO cohort[J]. J Urol, 2014, 191(6): 1816-1821. DOI: 10.1016/j.juro.2013.12.043.

56.Drake MJ, Mills IW, Noble JG. Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement[J]. J Urol, 2004, 171(3): 1199-1202. DOI: 10.1097/01.ju.0000110442.47593.ea.

57.Steffens JP, Wang X, Starr JR, et al. Associations between sex hormone levels and periodontitis in men: results from NHANES III[J]. J Periodontol, 2015, 86(10): 1116-1125. DOI: 10.1902/jop.2015.140530.

58.Steffens JP, Valenga HM, Santana LCL, et al. Role of testosterone and androgen receptor in periodontal disease progression in female rats[J]. J Periodontol, 2020, 91(4): 545-553. DOI: 10.1002/jper.19-0099.

59.De Paiva Gonçalves V, Ortega AAC, Steffens JP, et al. Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model[J]. J Periodontol, 2018, 89(4): 466-475. DOI: 10.1002/jper.17-0457.

60.Scheiermann C, Gibbs J, Ince L, et al. Clocking in to immunity[J]. Nat Rev Immunol, 2018, 18(7): 423-437. DOI: 10.1038/s41577-018-0008-4.

61.Baron KG, Reid KJ. Circadian misalignment and health[J]. Int Rev Psychiatry, 2014, 26(2): 139-154. DOI: 10.3109/09540261.2014.911149.

62.Morris CJ, Yang JN, Scheer F. The impact of the circadian timing system on cardiovascular and metabolic function[J]. Prog Brain Res, 2012, 199: 337-358. DOI: 10.1016/b978-0-444-59427-3.00019-8.

63.Alqaderi H, Goodson JM, Agaku I. Association between sleep and severe periodontitis in a nationally representative adult US population[J]. J Periodontol, 2020, 91(6): 767-774. DOI: 10.1002/jper.19-0105.

64.Patke A, Young MW, Axelrod S. Molecular mechanisms and physiological importance of circadian rhythms[J]. Nat Rev Mol Cell Biol, 2020, 21(2): 67-84. DOI: 10.1038/s41580-019-0179-2.

65.Park JS, Jeong Y, Jung J, et al. Shift work sleep disorder is closely associated with an increased risk for periodontal disease[J]. J Clin Periodontol, 2021, 48(8): 1066-1075. DOI: 10.1111/jcpe.13508.

66.Ebersole JL, Gonzalez OA. Mucosal circadian rhythm pathway genes altered by aging and periodontitis[J]. PLoS One, 2022, 17(12): e0275199. DOI: 10.1371/journal.pone.0275199.

67.Ma X, Chen X, Duan Z, et al. Circadian rhythm disruption exacerbates the progression of macrophage dysfunction and alveolar bone loss in periodontitis[J]. Int Immunopharmacol, 2023, 116: 109796. DOI: 10.1016/j.intimp.2023.109796.

68.Liu G, Sun Q, Wu X, et al. Clock genes are expressed in cementum and regulate the proliferation and mineralization of cementoblasts[J]. In Vitro Cell Dev Biol Anim, 2023, 59(1): 76-84. DOI: 10.1007/s11626-023-00748-4.

69.Bebas P, Goodall CP, Majewska M, et al. Circadian clock and output genes are rhythmically expressed in extratesticular ducts and accessory organs of mice[J]. Faseb J, 2009, 23(2): 523-533. DOI: 10.1096/fj.08-113191.

70.Ueda M, Kono J, Sengiku A, et al. Bmal1 regulates prostate growth via cell-cycle modulation[J]. Int J Mol Sci, 2022, 23(19): 11272. DOI: 10.3390/ijms231911272.

71.Inonu E, Hakki SS, Kayis SA, et al. The association between some macro and trace elements in saliva and periodontal status[J]. Biol Trace Elem Res, 2020, 197(1): 35-42. DOI: 10.1007/s12011-019-01977-z.

72.Liu Y, Li X, Liu S, et al. The changes and potential effects of zinc homeostasis in periodontitis microenvironment[J]. Oral Dis, 2023, 29(8): 3063-3077. DOI: 10.1111/odi.14354.

73.Gaur S, Agnihotri R. Trace mineral micronutrients and chronic periodontitis-a review[J]. Biol Trace Elem Res, 2017, 176(2): 225-238. DOI: 10.1007/s12011-016-0832-y.

74.Baima G, Iaderosa G, Corana M, et al. Macro and trace elements signature of periodontitis in saliva: a systematic review with quality assessment of ionomics studies[J]. J Periodontal Res, 2022, 57(1): 30-40. DOI: 10.1111/jre.12956.

75.Christudoss P, Selvakumar R, Fleming JJ, et al. Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma[J]. Indian J Urol, 2011, 27(1): 14-18. DOI: 10.4103/0970-1591.78405.

76.Daragó A, Klimczak M, Stragierowicz J, et al. Age-related changes in zinc, copper and selenium levels in the human prostate[J]. Nutrients, 2021, 13(5): 1403. DOI: 10.3390/nu13051403.

77.Najeeb S, Zafar MS, Khurshid Z, et al. The role of nutrition in periodontal health: an update[J]. Nutrients, 2016, 8(9): 530. DOI: 10.3390/nu8090530.

78.Ustianowski Ł, Ustianowska K, Gurazda K, et al. The role of vitamin C and vitamin D in the pathogenesis and therapy of periodontitis-narrative review[J]. Int J Mol Sci, 2023, 24(7). DOI: 10.3390/ijms24076774.

79.Zhang C, Han Y, Miao L, et al. Human β-defensins are correlated with the immune infiltration and regulated by vitamin D3 in periodontitis[J]. J Periodontal Res, 2023, 58(5): 986-996. DOI: 10.1111/jre.13159.

80.Adorini L, Penna G, Fibbi B, et al. Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasia [J]. Ann NY Acad Sci, 2010, 1193: 146-152. DOI: 10.1111/j.1749-6632.2009.05299.x.

81.Zendehdel A, Ansari M, Khatami F, et al. The effect of vitamin D supplementation on the progression of benign prostatic hyperplasia: a randomized controlled trial[J]. Clin Nutr, 2021, 40(5): 3325-3331. DOI: 10.1016/j.clnu.2020.11.005.