Objective  To evaluate the situation of conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2021, and compare with the relevant content guidelines published in 2017 and 2018. In order to find the changes in guidelines development and also provide implications for guidelines in China.

Method  CNKI, CBM and Wan Fang Data were searched to collect clinical practice guidelines in China published in 2021 from January 1st to December 31st. Two researchers independently screened literature, extracted relevant information such as conflict of interest disclosure and economic evidences, then, the analysis was performed by using Microsoft Excel 2019 software.

Result  A total of 164 clinical practice guidelines were finally included, in which 112 (68.29%) declared conflict of interest, 70 (42.68%) reported sources of funding, 30 (18.29%) considered economic evidence, and only 16 (9.76%) reported three aspects at the same time. Compared with the clinical practice guidelines published in 2017 and 2018 in China, the formulation of the guidelines has improved in terms of conflict of interest statements and funding, but the attention to economic evidence is still very low.

Conclusion  We should further improve the statement and management of conflict of interest and the attention to economic evidence in China's clinical practice guidelines, which will make the guidelines more objective, transparent and scientific.

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75. 中华医学会神经病学分会脑电图与癫痫学组. 中国围妊娠期女性癫痫患者管理指南[J]. 中华神经科杂志, 2021, 54(6): 539-544. [Chinese Society of EEG and Epilepsy. Chinese guidelines for the management of women with epilepsy during periconceptional period[J]. Chinese Journal of Neurology, 2021, 54(6): 539-544.] DOI: 10.3760/cma.j.cn113694-20201116-00879.

76. 中华医学会神经病学分会帕金森病及运动障碍学组, 中国医师协会神经内科医师分会帕金森病及运动障碍学组. 中国中晚期帕金森病运动症状治疗的循证医学指南[J]. 中国神经免疫学和神经病学杂志, 2021, 28(5): 347-360. [Parkinson's Disease and Motor Disorders Group, Neurological Branch, Chinese Medical Association; Parkinson's Disease and Motor Disorders Group, Neurophysicians Branch, Chinese Medical Association. Evidence-based medicine guidelines for the treatment of motor symptoms in patients with advanced Parkinson's disease in China[J]. Chinese Journal of Neuroimmunology and Neurology, 2021, 28(5): 347-360.] DOI: 10.3969/j.issn.1006-2963.2021.05.002.

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78. 中华医学会神经外科学分会, 中国医师协会急诊医师分会, 国家卫生健康委员会脑卒中筛查与防治工程委员会. 出凝血功能障碍相关性脑出血中国多学科诊治指南[J]. 中华神经外科杂志, 2021, 37(7): 649-662. [Chinese Society of Neurosurgery, Chinese Society of Emergency Physicians, Stroke Screening and Prevention Engineering Committee of the National Health Commission. Chinese multidisciplinary guidelines for the diagnosis and treatment of cerebral hemorrhage related to haemorrhagic and coagulative dysfunction[J]. Chinese Journal of Neurosurgery, 2021, 37(7): 649-662.] DOI: 10.3760/cma.j.cn112050-20210218-00087.

79. 中华医学会神经外科学分会, 国家卫健委脑卒中筛查与防治工程委员会, 海峡两岸医药卫生交流协会神经外科分会缺血性脑血管病学组. 大面积脑梗死外科治疗指南[J]. 中华医学杂志, 2021, 101(45): 3700-3711. [Chinese Society of Neurosurgery, the Stroke Screening and Prevention Engineering Committee of the National Health Commission; the Ischemic Cerebrovascular Disease Group of the Neurosurgery Branch of the Cross Strait Medical and Health Exchange Association. Guidelines for surgical treatment of massive cerebral infarction[J]. Chinese Medical Journal, 2021, 101(45): 3700-3711.] DOI: 10.3760/cma.j.cn112137-20210729-01687.

80. 中国医师协会神经介入专业委员会, 中国颅内动脉瘤计划研究组. 中国颅内破裂动脉瘤诊疗指南2021[J]. 中国脑血管病杂志, 2021, 18(8): 546-574. [Chinese Federation of Interventional Clinical Nerosciences, China Intracranial Aneursm Project Study Group. Chinese guidelines for diagnosis and treatment of ruptured intracranial aneurysm 2021[J]. Chinese Journal of Cerebrovascular Diseases, 2021, 18(8): 546-574.] DOI: 10.3969/j.issn.1672-5921.2021.08.007.

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