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Conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2021: a survey

Published on Feb. 25, 2023Total Views: 1168 timesTotal Downloads: 472 timesDownloadMobile

Author: Yan-Bo WANG 1 Ming-Juan ZHAO 2 Qiang WANG 3 Hui-Zhong XU 4 Hua TAO 5 Jia-Ping GUO 6 Xiu-Sen HUANG 7 Xue-Qun REN 8 Xian-TAO ZENG 2, 9

Affiliation: 1. Beijing General Hospital of the Chinese People's Armed Police Force, Beijing 100027, China 2. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 3. Department of Standardization Management, National Center for Medical Service Administration, National Health Commission of the People’s Republic of China, Beijing 100044, China 4. Department of Neurosurgery, Renmin Hospital of Dongtai City, Dongtai 224200, Jiangsu Province, China. 5. Department of Pharmacy, Zhengzhou Second Hospital, Zhengzhou 450015, China. 6. Department of Healthcare-Associated Infection Management, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China 7. Medical Department, Guangxi Qinzhou First People's Hospital, Qinzhou 535000, Guangxi Province, China 8. Institutes of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng 475000, Henan Province, China 9. Zhongnan Medical Journals Press, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Keywords: Clinical practice guidelines Conflict of interest Economics Financial resources Evidence-based medicine

DOI: 10.12173/j.issn.1004-5511.202210053

Reference: Wang YB, Zhao MJ, Wang Q, Xu HZ, Tao H, Guo JP, Huang XS, Ren XQ, Zeng XT. Conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2021: a survey[J]. Yixue Xinzhi Zazhi, 2023, 33(1): 8-49. DOI: 10.12173/j.issn.1004-5511.202210053.[Article in Chinese]

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Abstract

Objective  To evaluate the situation of conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2021, and compare with the relevant content guidelines published in 2017 and 2018. In order to find the changes in guidelines development and also provide implications for guidelines in China.

Method  CNKI, CBM and Wan Fang Data were searched to collect clinical practice guidelines in China published in 2021 from January 1st to December 31st. Two researchers independently screened literature, extracted relevant information such as conflict of interest disclosure and economic evidences, then, the analysis was performed by using Microsoft Excel 2019 software.

Result  A total of 164 clinical practice guidelines were finally included, in which 112 (68.29%) declared conflict of interest, 70 (42.68%) reported sources of funding, 30 (18.29%) considered economic evidence, and only 16 (9.76%) reported three aspects at the same time. Compared with the clinical practice guidelines published in 2017 and 2018 in China, the formulation of the guidelines has improved in terms of conflict of interest statements and funding, but the attention to economic evidence is still very low.

Conclusion  We should further improve the statement and management of conflict of interest and the attention to economic evidence in China's clinical practice guidelines, which will make the guidelines more objective, transparent and scientific.

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References

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75. 中华医学会神经病学分会脑电图与癫痫学组. 中国围妊娠期女性癫痫患者管理指南[J]. 中华神经科杂志, 2021, 54(6): 539-544. [Chinese Society of EEG and Epilepsy. Chinese guidelines for the management of women with epilepsy during periconceptional period[J]. Chinese Journal of Neurology, 2021, 54(6): 539-544.] DOI: 10.3760/cma.j.cn113694-20201116-00879.

76. 中华医学会神经病学分会帕金森病及运动障碍学组, 中国医师协会神经内科医师分会帕金森病及运动障碍学组. 中国中晚期帕金森病运动症状治疗的循证医学指南[J]. 中国神经免疫学和神经病学杂志, 2021, 28(5): 347-360. [Parkinson's Disease and Motor Disorders Group, Neurological Branch, Chinese Medical Association; Parkinson's Disease and Motor Disorders Group, Neurophysicians Branch, Chinese Medical Association. Evidence-based medicine guidelines for the treatment of motor symptoms in patients with advanced Parkinson's disease in China[J]. Chinese Journal of Neuroimmunology and Neurology, 2021, 28(5): 347-360.] DOI: 10.3969/j.issn.1006-2963.2021.05.002.

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