Objective  The 450 nm semiconductor blue laser surgical system was used to perform vapori-zation and incision of fresh endometrial tissue ex vivo under different conditions and endoscopic simulated surgery experiments to initially evaluate the safety, efficacy and feasibility of blue laser in gynecological surgical applications.  Method  8 fresh uteri were taken from each of the pregnant and non-pregnant swines. Vaporiza-tion and incision of endometiral tissue was performed using 450 nm core fiber. The moving speed of the stepper (V) is 1.0 mm/s, 2.0 mm/s, the distance (D) of the fiber head is adjusted to 0.5~1.0mm from the tissue, and the power of the laser is 5~30 W. Photographs after vaporization were recorded, and specimens were put into 4% paraformaldehyde for HE test. Vernier caliper was used to measure the thickness of the coagulation, width and depth of the vaporization. 8 postpartum uteri were used, and in contrast with plasma electrocut equipment, vitro simulated operation was done under the endoscope assisted. The specimens of postoperation was done HE staining.

Result  Blue laser acts on the endometrial tissue at different power (5~25 W), and as the laser power increases, the vaporization depth and vaporization width of the tissue gradually increases. A comparison of va-porization cutting experiments using a bipolar plasma electrosurgery device with the blue laser under endosco-py showed that the cut surface of blue laser was flatter. There was no obvious carbonization layer after the va-porization of the blue laser. The range of thermal damage for the blue laser was limited and controllable, and the thickness of the coagula-tion, the depth and width of the vaporization were stable. Compared to plasma electrocut equipment, the blue laser produces a relatively small range of thermal damage.

Conclusion  We con-cluded that the blue laser is a safe, effective and feasible surgical instrument for the treatment of the endometrial lesions. And the blue laser should be expected to become a new apparatus for physician of the department of gynaecology.

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