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HomeArticlesVol 32,2022 No.4Detail

Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis

Published on Aug. 25, 2022Total Views: 2853 timesTotal Downloads: 1205 timesDownloadMobile

Author: Ming-Zhen LI 1 Shao-Hua HE 1 Ying-Hui JIN 1, 2 Cheng CHEN 1 Si-Yu YAN 2 Yong-Bo WANG 2 Huan LIU 1 Zhi-Qing ZHOU 3 Han XIAO 4 Rui-Rui YANG 3 Li-Ming TAN 5

Affiliation: 1. Precision Medicine Centre, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China 2. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 3. Department of Thoracic Oncology, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China 4. Department of Gastrointestinal Oncology, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China 5. Department of Clinical Pharmacy, the Second People’s Hospital of Huaihua, Huaihua 418000 Hunan Province, China

Keywords: Circulating tumor cell Non-small cell lung cancer Prognosis Meta-analysis

DOI: 10.12173/j.issn.1004-5511.202203006

Reference: Li MZ, He SH, Jin YH, Chen C, Yan SY, Wang YB, Liu H, Zhou ZQ, Xiao H, Yang RR, Tan LM. Prognostic value of circulating tumor cells in patients with non-small cell lung cancer: a Meta-analysis[J]. Yixue Xinzhi Zazhi, 2022, 32(4): 250-259. DOI: 10.12173/j.issn.1004-5511.202203006.[Article in Chinese]

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Abstract

Objective  To systematically evaluate the prognostic value of circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC). 

Methods  We electronically searched CNIK, WanFang Data, CBM, VIP, PubMed, Web of Science, The Cochrane Library, and Embase database for literature regarding detection of baseline levels of CTCs and survival in NSCLC patients from inception to 28 September 2021. After screening for inclusion criteria, data extraction and quality assessment were performed followed by Meta-analysis using the RevMan 5.3 and Stata 15.0 software. 

Results  19 studies were included in this Meta-analysis with a total of 1,853 NSCLC patients. Meta-analysis revealed that NSCLC patients with high levels of CTCs had poorer progression-free survival (PFS) than those with low levels of CTCs [HR=2.49, 95% CI(1.50, 4.13), P=0.0004], but levels of CTCs had no significant predictive effect on overall survival (OS) [HR=1.18, 95%CI(0.70, 1.99), P=0.54]. 

Conclusions  Baseline CTCs levels have a significant predictive effect on PFS in NSCLC patients, but have no significant predictive ability on OS. This is an area which requires further study in the future.

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