Objective  To explore the high-risk factors for intracranial hemorrhage (ICH) in preterm infants.
Methods  We accessed the medical records of 283 preterm infants hospitalized from January 2019 to June 2019 in Zhongnan Hospital of Wuhan University, where MRI was to detect ICH in preterm infants. Logistic regression analysis of the factors related to ICH were conducted in all selected preterm infants.
Results  ICH, was detected by MRI in 68 preterm infants, representing 24.0%, and PVH-IVH (periventricular-intraventricular hemorrhage) was the most common type, with a detection rate of 11.0%. Single-factor analysis showed that there were ten factors showing statistically significant differ-ences between the ICH and non-ICH groups such as gestational age (χ2=29.438, P<0.001), delivery mode (χ2=30.576, P<0.001), postnatal skin bleeding (χ2=18.219, P<0.001) and intrauterine distress (χ2=9.690, P=0.002). Multivariate logistic regression analysis showed that preterm infants with gesta-tion age <32 weeks (OR=4.830, 95% CI: 2.385~9.785, P<0.05), eutocia (OR=6.510, 95%CI: 3.245~13.062, P<0.05), intrauterine distress (OR=5.424, 95% CI: 2.061~14.277, P<0.05) and postnatal skin bleeding (OR=2.559, 95% CI: 1.215~5.391, P<0.05) are more prone to ICH.
Conclusion  The most common type of ICH in preterm infants is PVH-IVH. Eutocia, intrauterine distress, postnatal skin bleed-ing and gestational age lower than 32 weeks are high-risk factors for ICH in preterm infants. Clinicians should take prevention and treatment measures as soon as possible to reduce the occurrence of ICH.

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