p75NTR, a low affinity neurotrophic factor receptor, is considered as a typical neural crest marker. It has been reported that p75NTR not only played an important role in the proliferation, migration, differentiation, survival and apoptosis of neural stem cells, was also involved in the regulation of morphogenesis and development of various tissues (including nerves, fat, liver, teeth, etc.). Especially in recent years, p75NTR has been reported to be functional in the initiation of tooth development, differentiation and mineralization of odontogenic stem cells, which has been gradually concerned by scholars. Thus, the purpose of this review is to discuss the structural characteristics and physiological functions of p75NTR, the biological effects and molecular mechanism during the tooth development and tissue regeneration.

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