The prevalence of obesity was increasing at all ages. Obesity was also a risk factor for various systemic diseases, including cardiovascular disease, peripheral vascular atherosclerosis, type 2 diabetes and so on. Endothelial cells were distributed in the vascular lumen, and regulated the homeostasis by coordinating the distribution of blood flow, nutrients, hormones and other cytokines, regulating inflammatory activity and angiogenesis. Obesity was accompanied by dysfunction of vascular endothelial cells and decrease of vascular density. Endothelial dysfunction was associated with obesity. In recent years, research on vascular endothelial cells or its related factors may become a potential treatment strategy to overcome obesity-related metabolic disorders.

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