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HomeArticlesVol 30,2020 No.5Detail

The research and progress of organoid in urinary tumors

Published on Oct. 16, 2020Total Views: 17117 timesTotal Downloads: 5059 timesDownloadMobile

Author: Jun-Wen XIAO 1 Kun HU 2 Gang-Lin SU 3 Hao SUN 1 Yu-Chen LIU 1*

Affiliation: 1. The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital , Key Laboratory of Urogenital Tumor System and Synthetic Biology , Shenzhen 518000, Guangdong Province, China 2. Department of Urology, Shenzhen Second People′s Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen 518000, Guangdong Province, China 3. Department of Clinical Medicine, Shantou University Medical College, Shantou 515041, Guangdong Province, China

Keywords: Urologic neoplasms Organoid 3D culture Cancer research

DOI: 10.12173/j.issn.1004-5511.2020.05.06

Reference: Xiao JW, Hu K, Su GL, Sun H, Liu YC. The research and progress of organoid in urinary tumors[J]. Yixue Xinzhi Zazhi, 2020, 30(5): 376-382. DOI: 10.12173/j.issn.1004-5511.2020.05.06.[Article in Chinese]

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Abstract

As an emerging 3D in vitro model system, organoids have the advantages of maintaining the original tissue genotype and biological characteristics, and can to some extent simulate the structural relationship between cells and matrix in in-situ tissues, as well as the development process and organ function.The tumor-like organs formed by tumor tissue culture with this technique can further reveal the changes of different information molecules and mechanisms in the process of tumor genesis, development and maintenance, and further understand the process of tumor genesis.In terms of urinary tumors, relevant experiments have proved that the 3D organ-like technology can make up for the defects of the traditional 2D model culture technology, and help to establish the model of urinary tumorigenesis and the molecular characteristics of the tumor phenotype, so as to discover the biomarkers of the origin of tumor cells in various urinary organs and tumor lineages.Great possibilities have been created for the development of innovative therapies using organoids, the identification of biomarkers for diagnosis or prognosis, the development of screening systems, and the development of patient-specific therapies.This article mainly describes the related research and progress of organoid tumors in common urologic neoplasms.

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References

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