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Role and related mechanisms of Porphyromonas gingivalis in the occurrence and development of digestive system tumors

Published on Apr. 01, 2026Total Views: 15 timesTotal Downloads: 1 timesDownloadMobile

Author: LI Jingya 1, 2 SUN Jiachun 1 KONG Jinyu 2 GAO Shegan 1, 2

Affiliation: 1. Department of Gastroenterology, Cancer Hospital, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China 2. Henan Key Laboratory of Microecology and Esophageal Cancer Prevention and Treatment, Luoyang 471000, Henan Province, China

Keywords: Porphyromonas gingivalis Digestive system Tumor pathogenesis and progression Molecular mechanism

DOI: 10.12173/j.issn.1004-5511.202408034

Reference: Li JY, Sun JC, Kong JY, et al. Role and related mechanisms of Porphyromonas gingivalis in the occurrence and development of digestive system tumors[J]. Yixue Xinzhi Zazhi, 2026, 36(3): 342-347. DOI: 10.12173/j.issn.1004-5511.202408034. [Article in Chinese]

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Abstract

The pathogenic role of Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been well documented to extend far beyond the oral cavity. P. gingivalis can be specifically detected in digestive system tumor tissues, and its infection abundance is closely associated with tumor invasion, metastasis, and poor prognosis in patients. This study systematically reviews basic and clinical research on the association between P. gingivalis and digestive system tumors including oral cancer, esophageal cancer, pancreatic cancer, liver cancer, and colorectal cancer. The potential molecular mechanisms underlying P. gingivalis-induced tumor initiation and progression were further elucidated thoroughly, aiming to provide new theoretical basis and research directions for risk warning, early diagnosis, and targeted therapy of digestive system  tumors.

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