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HomeArticlesVol 33,2023 No.4Detail

A case of amyloid light amyloidosis involving multiorgan with hepatomegaly as the main manifestation

Published on Aug. 25, 2023Total Views: 12291 timesTotal Downloads: 2812 timesDownloadMobile

Author: Ya-Nan CHEN 1, 2, 3# Jia-Long LIU 1, 2, 3# Yi-Zhang LI 1, 2, 3 Ji-Xia ZHANG 1, 2, 3 Xian-Yan SHI 1, 2, 3 Jing LIU 1, 2, 3

Affiliation: 1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 2. Hubei Clinical Center of Intestinal and Colorectal Diseases, Wuhan 430071, China 3. Hubei Key Lab of Intestinal and Colorectal Diseases, Wuhan 430071, China #Co-first author: Ya-Nan CHEN and Jia-Long LIU

Keywords: Amyloidosis Light chain amyloidosis Multiple organ involvement

DOI: 10.12173/j.issn.1004-5511.202209054

Reference: Chen YN, Liu JL, Li YZ, Zhang JX, Shi XY, Liu J. A case of amyloid light amyloidosis involving multiorgan with hepatomegaly as the main manifestation[J]. Yixue Xinzhi Zazhi, 2023, 33(4): 285-290. DOI: 10.12173/j.issn.1004-5511.202209054.[Article in Chinese]

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Abstract

Amyloid light (AL) amyloidosis, also known as primary systemic amyloidosis, is a protein conformation disease, and is a clinical syndrome of functional failure of affected organs due to abnormal folding and deposition of insoluble fibrin in the extracellular region of organs or tissues. The diagnosis of AL-type amyloidosis is challenging because of its low incidence and complex clinical manifestations, and cases of multiple organ involvement are even rarer. We reported a case of AL-type amyloidosis with multiple organ involvement in order to provide refference for related diagnosis, treatment and prognosis.

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