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HomeArticlesVol 32,2022 No.5Detail

Inflammatory bowel disease and Helicobacter pylori infection

Published on Oct. 25, 2022Total Views: 14089 timesTotal Downloads: 3726 timesDownloadMobile

Author: Ming-Ming ZHU 1, 2, 3 Zhi-Hua RAN 4

Affiliation: 1. Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China 2. Shanghai Institute of Digestive Diseases, Shanghai 200127, China 3. Shanghai Inflammatory Bow-el Disease Research Center, Shanghai 200127, China 4. Department of Gastroenterology, Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201300, China

Keywords: Inflammatory bowel disease Crohn's disease Ulcerative colitis Helicobacter pylori Immune-related

DOI: 10.12173/j.issn.1004-5511.202205040

Reference: Zhu MM, Ran ZH. Inflammatory bowel disease and Helicobacter pylori infection[J]. Yixue Xinzhi Zazhi, 2022, 32(5): 370-375. DOI: 10.12173/j.issn.1004-5511.202205040.[Article in Chinese]

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Abstract

In recent years, there are different conclusions about the relationship between Helico-bacter pylori (HP) infection and inflammatory bowel disease (IBD), but most preclinical and retrospec-tive studies report that there is a negative association between HP and IBD. HP infection may reduce the risk of developing IBD. It is considered that this negative association is related to the history of the use of sulfasalazine and antibiotics, the immunomodulatory characteristics of HP and environmental factors. However, whether there is a direct causal relationship between the increased incidence of IBD and HP eradication is still uncertain. Although HP infection should be treated with eradication therapy, routine eradication of HP should be undertaken with caution for IBD patients or IBD susceptible gene carriers. The association between HP infection and IBD as well as the mechanism, and the development of IBD after eradication of HP will be discussed in this paper.

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References

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