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The progress of research into the role of D-lactic acid in the diagnosis of periprosthetic joint infection

Published on Jul. 23, 2021Total Views: 2786 timesTotal Downloads: 1897 timesDownloadMobile

Author: Zhi-Zhuo LI 1# Li-Jun SHI 2# Wei SUN 3

Affiliation: 1. Department of Orthopedics, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China 2. Department of Orthopedics, China-Japan Friendship Institute of Clinical Medicine, Peking Union Medical Col-lege, Beijing 100029, China 3. Beijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Beijing 100029, China

Keywords: Periprosthetic joint infection Biomarker Synovial fluid D-lactate

DOI: 10.12173/j.issn.1004-5511.202010026

Reference: Li ZZ, Shi LJ, Sun W. The progress of research into the role of D-lactic acid in the diagnosis of periprosthetic joint infection[J]. Yixue Xinzhi Zazhi, 2021, 31(4): 294-298. DOI: 10.12173/j.issn.1004-5511.202010026.[Article in Chinese]

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Abstract

Periprosthetic joint infection is a catastrophic complication after arthroplasty. However, at present, there is still no accurate and efficient method for the diagnosis of this serious problem. The most widely accepted diagnostic criteria of periprosthetic infection have been developed by the Ameri-can Musculoskeletal Infection Society but their complex clinical indicators are not readily available for clinical application. Some laboratory tests such as white blood cell count, erythrocyte sedimentation rate, C-reactive protein, interleukin and serum procalcitonin have a certain diagnostic value. However, these tests are easily affected by other factors such as systemic diseases, infections at other sites and the use of antibiotics. In recent years, increasingly attention has been paid to the value of synovial fluid bi-omarkers in the diagnosis of periprosthetic joint infection. In this article, we have reviewed the current clinical studies related to synovial fluid D-lactate and have analyzed the clinical value and research sta-tus of D-lactate in the diagnosis of periprosthetic joint infection.

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References

1.Kapadia BH, Berg RA, Daley JA, et al. Periprosthetic joint infection[J]. Lancet, 2015, 387(10016): 386-394. DOI: 10.1016/S0140-6736(14)61798-0.

2.Koh CK, Zeng I, Ravi S, et al. Periprosthetic joint infection is the main cause of failure for modern knee arthroplasty: an analysis of 11,134 Knees[J]. Clin Orthop Relat Res, 2017, 475(9): 2194-2201. DOI: 10.1007/s11999-017-5436-4.

3.Peel TN, Dowsey MM, Buising KL, et al. Cost analysis of debridement and retention for management of prosthetic joint infection[J]. Clin Microbiol Infect, 2013, 19(2): 181-186. DOI: 10.1111/j.1469-0691.2011.03758.x.

4.Marculescu CE, Mabry T, Berbari EF. Prevention of surgical site infections in joint replacement sur-gery[J]. Surg Infect, 2016, 17(2): 152-157. DOI: 10.1089/sur.2015.258.

5.Tande AJ, Patel R. Prosthetic joint infection[J]. Clin Microbiol Rev, 2014, 27(2): 302-345. DOI: 10.1016/j.idc. 2017.01.009.

6.王常德, 康鹏德, 裴福兴,等. 全关节置换术后假体周围感染诊断的研究进展[J]. 中国矫形外科杂志, 2016, 24(10): 907-910. DOI: 10.3977/j.issn.1005-8478. 2016.10.10. [Wang CD, Kang PD, Pei FX, et al. Diagnosis of periprosthetic joint infection after total joint arthroplasty[J]. Orthopedic Journal of China, 2016, 24(10): 907-910.]

7.Parvizi J, Zmistowski B, Berbari EF, et al. New definition for periprosthetic joint infection: from the workgroup of the musculoskeletal infection society[J]. Clin Orthop Relat Res, 2011, 469(11): 2992-2994. DOI: 10.1007/s11999-011-2102-9.

8.Javad, Parvizi, Timothy L, et al. The 2018 definition of periprosthetic hip and knee infection: an evi-dence-based and validated criteria[J]. J Arthroplasty, 2018, 33(5): 1309-1314. DOI: 10.1016/j.arth.2018.02.078.

9.Shirley Z, Romero J, Estrera K. Definition of periprosthetic joint infection of the hip and new tools for diagnosis[J]. Curr Orthop Pract, 2017, 28(3): 268-271. DOI: 10.1097/BCO.0000000000000506.

10.Shahi A, Tan TL, Kheir MM, et al. Diagnosing periprosthetic joint infection: and the winner is?[J]. J Ar-throplasty, 2017, 32(9S): S232-S235. DOI: 10.1016/j.arth. 2017.06.005.

11.蔡东峰, 刘毅. α-防御素在关节假体周围感染诊断中的作用及应用前景[J]. 中国矫形外科杂志, 2017, 25(11): 1005-1008. DOI: 10.3977/j.issn.1005- 8478.2017.11.09. [Cai DF, Liu Y. Role and application prospect of α-defensins in diagnosis of peri-prosthetic infection[J]. Orthopedic Journal of China, 2017, 25(11): 1005-1008.]

12.Lee YS, Koo KH, Kim HJ, et al. Synovial fluid biomarkers for the diagnosis of periprosthetic joint infec-tion[J]. J Bone Joint Surg Am, 2017, 99(24): 2077-2084. DOI: 10.2106/JBJS.17.00123.

13.Yermak K, Karbysheva S, Perka C, et al. Performance of synovial fluid D-lactate for the diagnosis of periprosthetic joint infection: a prospective observational study[J]. J Infect, 2019, 79(2): 123-129. DOI: 10.1016/j.jinf.2019.05.015.

14.Karbysheva S, Yermak K, Grigoricheva L, et al. Synovial fluid D-lactate-A novel pathogen-specific bi-omarker for the diagnosis of periprosthetic joint infection[J]. J Arthroplasty, 2020, 35(8): 2223-2229.e2. DOI: 10.1016/j.arth. 2020.03.016.

15.Ewaschuk JB, Naylor JM, Zello GA. D-lactate in human and ruminant metabolism[J]. J Nutr, 2005, 135(7): 1619-1625. DOI: 10.1038/sj.ijo.0802592.

16.Smith SM, Eng RH, Buccini F. Use of D-lactic acid measurements in the diagnosis of bacterial infec-tions[J]. J Infect Dis, 1986, 154(4): 658-664. DOI: 10.1093/infdis/ 154.4.658.

17.Smith SM, Eng RH, Campos JM, et al. D-lactic acid measurements in the diagnosis of bacterial infec-tions[J]. J Clin Microbiol, 1989, 27(3): 385-388. DOI: 10.1093/infdis/154.4.658.

18.Marcos MA, Vila J, Gratacos J, et al. Determination of D-lactate concentration for rapid diagnosis of bacterial infections of body fluids[J]. Eur J Clin Microbiol Infect Dis, 1991, 10(11): 966-969. DOI: 10.1007/BF02005455.

19.Kortekangas P , Peltola O , Toivanen A , et al. Synovial-fluid D-lactic acid in bacterial and other acute joint effusions[J]. Scand J Rheumatol, 1994, 23(4): 203-205. DOI: 10.3109/03009749409103061.

20.陈志, 周宗科. 髋、膝关节置换术后假体周围感染的诊治进展[J]. 实用骨科杂志, 2017, 23(3): 247-251. DOI: 10.13795/j.cnki.sgkz.2017.03.014. [Chen Z, Zhou ZK. Progress in diagnosis and treatment of peripros-thetic joint infection after hip and knee arthroplasty[J]. Journal of Practical Orthopaedics, 2017, 23(3): 247-251.]

21.孙彬. 人工关节置换术后假体周围感染诊断的研究进展[J]. 中国微创外科杂志, 2019, 19(5): 439-444. DOI:10.3969/j.issn.1009-6604.2019.05.014. [Sun B. Research progress on the diagnosis of prosthesis peri-prosthesis infection after artificial joint replacement[J]. Chinese Journal of Minimally Invasive Sur-gery, 2019, 19(5): 439-444.]

22.袁俊, 冯建民. 人工关节置换术后假体周围感染的病原学诊断研究进展[J]. 中华关节外科杂志(电子版), 2016, 10(4): 432-435. DOI:10.3877/cma.j.issn.1674-134X.2016.04.013. [Yuan J, Feng JM. Etiological diagnosis of periprosthetic joint infection[J]. Chinese Journal of Joint Surgery(Electronic Version), 2016, 10(4): 432-435.]

23.刘鹏, 曹国定, 常彦峰, 等. 人工关节置换术后假体周围感染的研究进展[J]. 解放军医学杂志, 2020, 45(11): 1196-1206. DOI: 10.11855/j.issn.0577-7402.2020.11.15. [Liu P, Cao DG, Chang YF, et al. Research pro-gress on periprosthetic joint infection after arthroplasty[J]. Medical Journal of Chinese People's Liber-ation Army, 2020, 45(11): 1196-1206.]