Prostate cancer (PCa) is one of the most common male reproductive tumors. If the tumor characteristics, treatment and prognosis can be accurately predicted through in vivo and in vitro experiments, it will greatly reduce unnecessary pain for patients. The patient-derived tu-mor xenografts (PDX) models which are widely used in preclinical and precision medicine re-search, can directly transplant tumors from different individuals into immunodeficient mice. This article will introduce the development, construction and application of the PCa PDX model in detail.

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