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HomeArticlesVol 30,2020 No.6Detail

Evidence-based clinical practice guideline for chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19 : evidence evaluation (1)

Published on Dec. 05, 2020Total Views: 16059 timesTotal Downloads: 1848 timesDownloadMobile

Author: Ming-Zhen LI 1 Xia-Mei XU 2 Shao-Hua HE 1 Mei-Hua SHEN 3 Ying-Hui JIN 1, 4* Li-Ming TAN 5*

Affiliation: 1. Precision Medicine Centre, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China 2. Department of Intensive Care Unit, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China 3. Department of Respiratory Medicine, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China 4. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 5. Department of Clinical Pharmacy, the Second People’s Hospital of Huaihua, Huaihua 418000, Hunan Province, China

Keywords: COVID-19 Methodology quality Overview of systematic review

DOI: 10.12173/j.issn.1004-5511.2020.06.04

Reference: Li MZ, Xu XM, He SH, Shen MH, Jin YH, Tan LM. Evidence-based clinical practice guideline for chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: Evidence evaluation (1)[J]. Yixue Xinzhi Zazhi, 2020, 30(6): 442-448. DOI: 10.12173/j.issn.1004-5511.2020.06.04.[Article in Chinese]

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Abstract

Objective  To re-evaluate the systematic evaluation of the evidence included in the team's published clinical practice guidelines for COVID-19 drug prevention, diagnosis, treatment, and discharge management. 

Methods  we were electronically searched to collect systematic evaluation/meta-analysis of covid-19 treatment form PubMed, The Cochrane Library, Embase, CNKI and WanFang databases, and important medical journals, preprinted platform and clinical trial registry. The retrieval time was December 1, 2019 to July 8, 2020.AMSTAR 2 tool was used to evaluate the methodological quality of the included system evaluation. 

Results  A total of 6 systematic evaluations/meta-analyses were included, four were drug therapy and two were immunotherapy. The evaluation results of AMSTAR 2 showed that the methodological quality of 1 study was high, 3 were medium, 1 was low, and 1 was extremely low. Methodology deficiencies are mainly reflected in the scheme and registration, analysis methods and funding sources, and so on. 

Conclusions  The methodological quality of the systematic evaluation of COVID-19 treatment is extremely low to high, and some conclusions cannot be determined. High-quality studies with large samples and long-term follow-up are still needed to confirm this.

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