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Application of Excel and Visual Basic program language in exploring the impact of MicroRNA-501 on the survival of patients with lung squamous cell carcinoma

Published on Oct. 16, 2020Total Views: 4592 timesTotal Downloads: 2571 timesDownloadMobile

Author: Zhi-Yuan HUANG 1# Wen-Hao JIANG 1# Fu-Gui YANG 1 Lei ZHU 1 Lin DONG 1 Ling-Wei WANG 1 Ming-Hao FENG 1 Liang WEI 2 Guang-Xue WANG 2* Qin-Chuan LI 1, 2*

Affiliation: 1. Department of Cardiothoracic Surgery, East Hospital Affiliated to Tongji University, Shanghai 200120, China 2. Center for Translational Medicine, East Hospital affiliated to Tongji University, Shanghai 200120, China

Keywords: Excel software Visual Basic program tools MicroRNA miR-501 Survival analysis The product limit method Log-rank test

DOI: 10.12173/j.issn.1004-5511.2020.05.02

Reference: Huang ZY, Jiang WH, Yang FG, Zhu L, Dong L, Wang LW, Feng MH, Wei L, Wang GX, Li QC. Application of Excel and Visual Basic program language in exploring the impact of MicroRNA-501 on the survival of patients with lung squamous cell carcinoma [J]. Yixue Xinzhi Zazhi, 2020, 30(5): 336-344. DOI: 10.12173/j.issn.1004-5511.2020.05.02.[Article in Chinese]

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Abstract

Objective  applying Excel software accompany with Visual Basic program tools to explore how does the expression level of miR-501 in tumor tissue affect the survival time of lung squamous cell carcinoma patients.

Methods  Obtain the data of the survival time of lung Squamous cell carcinoma patients and the expression level of miR-501 in their tumor tissue from Kmplot databases. Import them into Excel software. Draw Graph User Interface and Write program to perform survival analysis of these lung Squamous cell carcinoma patients. 

Result  Lung Squamous cell carcinoma patients who have a higher expression level of miR-501 live longer than ones who have a lower expression level of miR-501. The log-rank test between higher miR-501 group and lower miR-501 group shows difference of survial time between two group was statistically significant(P<0.05).

Conclusion  Excel with Visual Basic program tools contributes great in survival analysis and log-rank test of survival analysis data of cancer patients. The result is credible.

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References

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