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HomeArticlesVol 34,2024 No.5Detail

Analysis of the influencing factors on serum reversal in HIV-exposed children

Published on Jun. 01, 2024Total Views: 1073 timesTotal Downloads: 411 timesDownloadMobile

Author: LI Xiaoling 1 WU Xiaodong 2 YUAN Dongmei 1 HUANG Ting 1 LIU Xiaoning 3 XIA Junxia 4 LI Shaqian 1 HUANG Haiying 1 HE Yun 3

Affiliation: 1. Department of Preventive Health and Nosocomial Infection Management, Shenzhen Third People's Hospital, Shenzhen 518112, Guangdong Province, China 2. Information Section, Shenzhen Third People's Hospital, Shenzhen 518112, Guangdong Province, China 3. Department of Infection and Immunology, Shenzhen Third People's Hospital, Shenzhen 518112, Guangdong Province, China 4. Department of Obstetrics, Shenzhen Third People's Hospital, Shenzhen 518112, Guangdong Province, China

Keywords: HIV-infected pregnant women HIV-exposed children Serum reversal Early infant diagnosis Mother-to-child transmission Nucleic acid test Influencing factors

DOI: 10.12173/j.issn.1004-5511.202311087

Reference: Li X L, Wu XD, Yuan DM, Huang T, Liu XN, Xia JX, Li SQ, Huang HY, He Y. Analysis of the influencing factors on serum reversal in HIV-exposed children[J]. Yixue Xinzhi Zazhi, 2024, 34(5): 516-522. DOI: 10.12173/j.issn.1004-5511.202311087.[Article in Chinese]

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Abstract

Objective  To study the factors influencing serum reversal in HIV-exposed children.

Methods  The general information, clinical data, and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January 2019 to December 2021.

Results   All 49 HIV-exposed children were tested negative for HIV nucleic acid at 48 h, 6 weeks, and 3 months of age. The serum reversal rates at 12, 18 and 21 months were 59.18%, 93.87% and 100%, respectively. Whether the serum of HIV-exposed children was reversed at 12 months of age was not related to the maternal delivery, anti-retroviral therapy initiation time, nucleic acid test results, CD4+T lymphocyte count (P>0.05). It was not related to children’s sex, gestational age, birth weight, and the type of blocking drug used (P>0.05).

Conclusion  No clear influencing factors were found for serum reversal in HIV-exposed 12-month-old children. The consistency between nucleic acid detection and final serum reversal was 100%. In order to exclude the possibility of HIV infection as soon as possible and reduce family concerns, three times of negative nucleic acid results before 3 months of age in HIV-exposed children may be considered as a substitute for serum reversal.

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References

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