Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Choroidopathy caused by lupus is a rare complication of SLE, and is a sensitive indicator of disease activity and usually portends a poor prognosis. It is generally improved after SLE is controlled. This article reports a case of SLE with bilateral choroidopathy combined with serous retinal detachments as the initial manifestation, which was confirmed by multimodal ophthalmic imaging. The choroidopathy in this patient was controlled after aggressive treatment.

1.Silpa-archa S, Lee JJ, Foster CS. Ocular manifestations in systemic lupus erythematosus[J]. Br J Ophthalmol, 2016, 100(1): 135-41. DOI: 10.1136/bjophthalmol-2015-306629.

2.Jawahar N, Walker JK, Murray PI, et al. Epidemiology of disease-activity related ophthalmological manifestations in Systemic Lupus Erythematosus: A systematic review[J]. Lupus, 2021, 30(14): 2191-2203. DOI: 10.1177/09612033211050337.

3.Hasanreisoglu M, Gulpinar Ikiz GD, Kucuk H, et al. Acute lupus choroidopathy: multimodal imaging and differential diagnosis from central serous chorioretinopathy[J]. Int Ophthalmol, 2018, 38(1): 369-374. DOI: 10.1007/s10792-016-0433-y.

4.Yao Y, Wang HX, Liu LW, et al. Acute choroidal involvement in lupus nephritis: A case report and review of literature[J]. World J Clin Cases, 2022, 10(19): 6520-6528. DOI: 10.12998/wjcc.v10.i19.6520.

5.Lee I, Zickuhr L, Hassman L. Update on ophthalmic manifestations of systemic lupus erythematosus: pathogenesis and precision medicine[J]. Curr Opin Ophthalmol, 2021, 32(6): 583-589. DOI: 10.1097/ICU.0000000000000810.

6.Braga J, Rothwell R, Oliveira M, et al. Choroid thickness profile in patients with lupus nephritis[J]. Lupus, 2019, 28(4): 475-482. DOI: 10.1177/0961203319828525.

7.Nguyen QD, Uy HS, Akpek E K, et al. Choroidopathy of systemic lupus erythematosus[J]. Lupus, 2000, 9(4): 288-298. DOI: 10.1191/096120300680199024.

8.Liu XY, Peng XY, Wwang S, et al. Features of optical coherence tomography for the diagnosis of vogt-koyanagi-Harada Disease[J]. Retina, 2016, 36(11): 2116-2123. DOI: 10.1097/IAE.0000000000001076.

9.Lee KR, Peng LY, Iqbal TB, et al. Role of angiography in systemic lupus rrythematosus-induced choroiditis[J]. Ocul Immunol Inflamm, 2018, 26(8): 1146-1149. DOI: 10.1080/09273948.2017.1298821.

10.中华医学会风湿病学分会, 国家皮肤与免疫疾病临床医学研究中心, 中国系统性红斑狼疮研究协作组. 2020中国系统性红斑狼疮诊疗指南[J].中华内科杂志, 2020, 59(3): 172-185. [Chinese Rheumatology Association, National Clinical Researeh Center for Dermatologie and Immunologic

Diseases, Chinese Systemic Lupus Erythematosus Treatment and Researeh Croup. 2020 Chinese guidelines for the diagnosis and trcatment of systemic lupus crythematosus[J]. Chinese Journal of Internal Medicine, 2020, 59(3): 172-185.] DOI: 10.3760/cma.j.issn.0578-1426.2020.03.002.

11.Tang C, Godfrey T, Stawell R, et al. Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects[J]. Intern Med J, 2012, 42(9): 968-978. DOI: 10.1111/j.1445-5994.2012.02886.x.

12.Shimura M, Tatehana Y, Yasuda K, et al. Choroiditis in systemic lupus erythematosus: systemic steroid therapy and focal laser treatment[J]. Jpn J Ophthalmol, 2003, 47(3): 312-315. DOI: 10.1016/s0021-5155(03)00012-1.