Conjunctival extramedullary plasmacytoma: a case study and literature review

Published on Dec. 25, 2022Total Views: 2313 timesTotal Downloads: 1844 timesDownloadMobile

Author: Yun-Feng XU Ming YAN

Affiliation: Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Keywords: Extramedullary plasmacytoma Case report Pathological examination Literature re-view

DOI: 10.12173/j.issn.1004-5511.202110038

Reference: Xu YF, Yan M. Conjunctival extramedullary plasmacytoma: a case study and literature review[J]. Yixue Xinzhi Zazhi, 2022, 32(6): 473-476. DOI: 10.12173/j.issn.1004-5511.202110038.[Article in Chinese]

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Extramedullary plasmacytoma (EMP) is a rare type of plasmacytoma characterized by the abnormal proliferation of plasma cells. It can be divided into primary and secondary types according to the cause and often occurs in the head and neck, while conjunctival EMP usually develops in the form of primary EMP. At present, domestic and foreign research on conjunctival EMP is relatively rare. This article reports a case of conjunctival EMP in a 43-year-old man. The patient had only limited lesions in the extramedullary conjuncti-va, and the tumor was visible in the conjunctiva and bulbar conjunctiva of the right eyelid. This article reports the treatment process and prognosis of this patient and reviews the related literature on conjunctival EMP, aim-ing to provide a reference for its correct diagnosis and treatment.

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1.Zhang QY, Li TC, Lin J, et al. Coexistence of cervical extramedullary plasmacytoma and squa-mous cell carcinoma: a case report[J]. World J Clin Cases, 2021, 9(24): 7110-7116. DOI: 10.12998/wjcc.v9.i24.7110. 

2.Schulze B, Kuchenbecker J, Fleige B, et al. Solitary extramedullary plasmocytoma of the con-junctiva[J]. Ophthalmologe, 2009, 106(2): 149-151. DOI: 10.1007/s00347-008-1779-y. 

3.傅思莹,匡忠生,任明能, 等. 12例髓外浆细胞瘤临床病理分析[J]. 临床与病理杂志, 2019, 39(6): 1192-1197. [Fu SY, Kuang ZS, Ren MN, et al. Extramedullary plasmacytoma: clinicopathological analyses of 12 cases[J]. Journal of Clinical and Pathological Research, 2019, 39(6): 1192-1197.] DOI: CNKI:SUN:WYSB.0.2019-06- 006.

4.Ashraf MJ, Azarpira N, Khademi B, et al. Extramedullary plasmacytoma of the nasal cavity re-port of three cases with review of the literature[J]. Iran Red Crescent Med J, 2013, 15(4) : 363-366. DOI: 10.5812/ircmj.2209.

5.Kulkarni S, Shroff JA, Meghana SM, et al. Solitary plasmacytoma of mandible: an unusual bilat-eral presentation[J]. Autops Case Rep, 2021, 11: e2021298. DOI: 10.4322/acr.2021.298. 

6.Sokhi DS, Mithi CW, Ebrahim FA, et al. Collet-Sicard syndrome due to concurrent extramedul-lary intracranial plasmacytoma and jugular venous sinus thrombosis in multiple myeloma[J]. Clin Case Rep, 2021, 9(7): e04457. DOI: 10.1002/ccr3.4457.

7.Li Y, Jiang Y, Su Z, et al. Radical resection of solitary tracheal extramedullary plasmacytoma under non-intubated anesthesia: a case report[J]. Ann Transl Med, 2021, 9(15): 1265. DOI: 10.21037/atm-21-1786.

8.Alshomar KM, Altariqi SM, Alrikabi AC, et al. Primary extramedullary plasmacytoma of the eye-lid conjunctiva - a case report and review of the literature[J]. Ann Med Surg (Lond), 2020, 55: 1-4. DOI: 10.1016/j.amsu.2020.04.028.

9.Woo Park C, Kim W, Jae Oh I, et al. Solitary extramedullary plasmacytoma presenting as an endobronchial mass[J]. Intern Med, 2013, 52(18): 2113-2116. DOI: 10.2169/internalmedicine.52.0572.

10.Santos-Bueso E, Calvo-González C, Troyano J, et al. Ocular infiltration in a patient with multiple myelo-ma[J]. Arch Soc Esp Oftalmol, 2005, 80(12): 725-728. DOI: 10.4321/s0365-66912005001200008.

11.Yumori JW, Ilsen P, Bright DC. Conjunctival plasmacytoma[J]. Optometry, 2010, 81(5): 234-239. DOI: 10.1016/j.optm. 2009.11.006.

12.Bove V, Garrido D, Riva E. Young age and autologous stem cell transplantation are associated with improved survival in newly diagnosed multiple myeloma[J]. Hematol Transfus Cell Ther, 2021, 43(3): 295-302. DOI: 10.1016/j.htct.2020.06.014. 

13.Jiang J, Liu Y, Wang F, et al. An unusual occurrence of solitary extramedullary plasmacytoma in the conjunctiva[J]. Oncol Lett, 2012, 4(2): 245-246. DOI: 10.3892/ol.2012. 726. 

14.Müller-Jensen K, Frenzel H. Solitary extramedullary plasmacytoma of the conjunctiva[J]. Klin Monbl Augenheilkd, 1997, 211(2): 128-130. DOI: 10.1055/s-2008-1035109.

15.Wysocki MS, Weber K. Solitary extramedullary plasmacytoma of the thyroid gland in a patient with subclinical hyperthyroidism[J]. AACE Clin Case Rep, 2021, 7(5): 303-306. DOI: 10.1016/j.aace.2021.03.002. 

16.Tetsumoto K, Iwaki H, Inoue M. IgG-kappa extramedullary plasmacytoma of the conjunctiva and orbit[J]. Br J Ophthalmol, 1993, 77(4): 255-257. DOI: 10.1136/bjo.77. 4.255. 

17.Mohamed S, Silvasi T, Kubat A, et al. Unilateral multiple extramedullary plasmacytoma of the choroid and conjunctiva: a case report[J]. Journal of VitreoRetinal Diseases, 2019, 4(2): 152-156. DOI: 10.1177/2474126419893175.

18.张蓓, 姚玉峰. 双眼睑结膜髓外浆细胞瘤一例[C]. 2011年浙江省眼科学术会议论文集, 2011.

19.Lim CC, Soong TK, Chuah KC, et al. Extramedullary plasmacytoma of the eyelid: a case report and review of literature[J]. Clin Exp Optom, 2013, 96(3): 349-351. DOI: 10.1111/j.1444-0938.

20.Di Stadio A, Ralli M, Messineo D, et al. Septal nasal extramedullary plasmacytoma: a rare tumor in an unusual area[J]. Ear Nose Throat J, 2021, 100(5_suppl): 805S-807S. DOI: 10.1177/0145561320911735.