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HomeArticlesVol 32,2022 No.1Detail

The role of autophagy related signal transduction pathways in bone metabolism

Published on Feb. 25, 2022Total Views: 8568 timesTotal Downloads: 3890 timesDownloadMobile

Author: Zhi-Zhuo LI 1 Li-Jun SHI 2 Fu-Qiang GAO 3 Wei SUN 3

Affiliation: 1. Department of Orthopedics, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China 2. Department of Orthopedics, Peking Union Medical College, China-Japan Friendship institute of Clinical Medicine, Beijing 100029, China 3. Beijing Key Laboratory of Immune Inflammatory Disease, China-Japan Friendship Hospital, Beijing 100029, China

Keywords: Autophagy Signal transduction pathway Bone metabolism Osteoblast Osteoclast

DOI: 10.12173/j.issn.1004-5511.202011032

Reference: Li ZZ, Shi LJ, Gao FQ, Sun W. The role of autophagy related signal transduction pathways in bone metabolism[J]. Yixue Xinzhi Zazhi, 2022, 32(1): 64-68. DOI: 10.12173/j.issn.1004-5511.202011032.[Article in Chinese]

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Abstract

Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation. The main cells involved in bone me-tabolism include osteoblasts and osteoclasts, which play an important role in bone development and maintenance. It has been found that the level of autophagy is regulated by sirtuin1 (SIRT1) and mito-gen-activated protein kinase 8 (MAPK8)/forkhead box O3 (FOXO3) in osteoblasts. In osteoclasts, the level of autophagy is regulated mainly by Bcl-2 interacting coiled-coil protein 1 (Beclin-1), p62/sequestosome 1 (p62/SQSTM1), mammalian target of rapamycin (mTOR) and hypoxia-inducible factor-1α (HIF-1α). The main focus of this article is a discussion of the autophagy related signal trans-duction pathways in bone metabolism and an analysis of the regulation of autophagy in osteoblasts and osteoclasts.

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