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HomeArticlesVol 31,2021 No.3Detail

Research advances into the use of dendritic cells in head and neck squamous cell car-cinoma therapy

Published on May. 26, 2021Total Views: 17642 timesTotal Downloads: 4541 timesDownloadMobile

Author: Xin-Yuan ZHANG 1, 2, 3, 4, 5 Zhi-Gang CAI 1, 2, 3, 4, 5 Shang XIE 1, 2, 3, 4, 5

Affiliation: 1. Peking University School of Stomatology, Beijing 100081, China 2. Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology, Beijing 100081, China 3. National Clinical Research Center for Oral Diseases, Beijing 100081, China 4. National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China 5. Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China

Keywords: Head and neck squamous cell carcinoma Tumor microenvironment Dendritic cells Im-munotherapy

DOI: 10.12173/j.issn.1004-5511.202102006

Reference: Zhang XY, Cai ZG, Xie S. The dendritic cells in head and neck squamous cell carcinoma[J]. Yixue Xinzhi Zazhi, 2021, 31(3): 204-209. DOI: 10.12173/j.issn.1004-5511.202102006.[Article in Chinese]

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors in the world. Current treatment involves a combination of surgery, radiotherapy and chemotherapy. However, novel therapy methods are urgently needed to improve its 5-years survival rate and poor prognosis. The exploration of the complex relationships within the tumor immune microenvironment has led to various clinical trials related to immunotherapy which have attracted much attention, including the application of dendritic cells. Dendritic cells are natural antigen-presenting cells that can stimulate anti-tumor immune responses. Encouraging work has been carried out using these cells as vaccines against some tumors. This review aims to introduce the progress in research into dendritic cell related therapy for HNSCC.

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