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HomeArticlesVol 31,2021 No.3Detail

Current status of research on olfactory dysfunction in COVID-19 patients

Published on May. 18, 2021Total Views: 3394 timesTotal Downloads: 1385 timesDownloadMobile

Author: Na WANG 1, 2 Heng GONG 3 Chao-Yang WANG 1 Wen-Zhong XIE 4 Xue-Qun REN 1

Affiliation: 1. Institutes of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng 475000, Henan Province, China 2. School of Nursing and Health, Henan University, Kaifeng 475004, Henan Province, China 3. Department of Otolaryngology, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan 442008, Hubei Province, China 4. Kaifeng University Health Science Center, Kaifeng 475004, Henan Province, China

Keywords: COVID-19 Olfactory dysfunction Symptom Early diagnose

DOI: 10.12173/j.issn.1004-5511.202008015

Reference: Wang N, Gong H, Wang CY, Xie WZ, Ren XQ. Current status of research on olfactory dysfunction in COVID-19 patients[J]. Yixue Xinzhi Zazhi, 2021, 31(3): 224-230. DOI: 10.12173/j.issn.1004-5511.202008015.[Article in Chinese]

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Abstract

COVID-19 is caused by SARS-CoV-2, and the infection mainly targets the respiratory system. Recently, more and more reports have highlighted nervous system effects of SARS-CoV-2 infection, mainly manifested as olfactory dysfunction, often accompanied by ageusia. The purpose of this article is to review the relevant studies on olfactory dysfunction caused by SARS-CoV-2 infection, and to summarize its causes, incidence, characteristics and current treatments in COVID-19, so as to deepen clinical medical staff's understanding of COVID-19, and to promote the identification, diagnosis and management of patients with these symptoms.

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References

1.  Mahase E. Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate[J]. BMJ, 2020, 368: m641. DOI: 10.1136/bmj.m641.

2.  Li LQ, Huang T, Wang YQ, et al. COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis[J]. J Med Virol, 2020, 92(6): 577-583. DOI: 10.1002/jmv.25757.

3.  Fu L, Wang B, Yuan T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis[J]. J Infect, 2020, 80(6): 656-665. DOI: 10.1016/j.jinf.2020.03.041.

4.  Gengler I, Wang JC, Speth MM, et al. Sinonasal pathophysiology of SARS-CoV-2 and COVID-19: a sys-tematic review of the current evidence[J]. Laryngoscope Investig Otolaryngol, 2020, 5(3): 354-359. DOI: 10.1002/lio2.384.

5.  Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?[J]. Rhinology, 2020, 58(3): 299-301. DOI: 10.4193/Rhin20.114.

6.  Coelho DH, Kons ZA, Costanzo RM, et al. Subjective changes in smell and taste during the COVID-19 pandemic: a national survey-preliminary results[J]. Otolaryngol Head Neck Surg, 2020: 194599820929957. DOI: 10.1177/0194599820929957.

7.  Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected pa-tients[J]. N Engl J Med, 2020, 382(12): 1177-1179. DOI: 10.1056/NEJMc2001737.

8.  Whitcroft KL, Hummel T. Olfactory dysfunction in COVID-19: diagnosis and management[J]. JAMA, 2020, 323(24): 2512-2514. DOI: 10.1001/jama.2020.8391.

9.  Printza A, Constantinidis J. The role of self-reported smell and taste disorders in suspected COVID 19[J]. Eur Arch Otorhinolaryngol, 2020: 1-6. DOI: 10.1007/s00405-020-06069-6.

10. Smith TD, Bhatnagar KP. Anatomy of the olfactory system[J]. Handb Clin Neurol, 2019, 164: 17-28. DOI: 10. 1016/b978-0-444-63855-7.00002-2.

11. Devere R. Disorders of taste and smell[J]. Continuum (Minneap Minn), 2017, 23(2): 421-446. DOI: 10.1212/CON.0000000000000463.

12. Garcia-Esparcia P, Schlüter A, Carmona M, et al. Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain[J]. J Neuropathol Exp Neurol, 2013, 72(6): 524-539. DOI: 10.1097/NEN. 0b013e318294fd76.

13. Umer F, Haji Z, Zafar K. Role of respirators in controlling the spread of novel coronavirus (COVID-19) amongst dental healthcare providers: a review[J]. Int Endod J, 2020, 53(8): 1062-1067. DOI: 10.1111/iej.13313.

14. Lovato A, De Filippis C. Clinical presentation of COVID-19: a systematic review focusing on upper airway symptoms[J]. Ear Nose Throat J, 2020, 99(9): 569-576. DOI: 10.1177/0145561320920762.

15. Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis[J]. Gastroenter-ology, 2020, 159(1): 81-95. DOI: 10.1053/j.gastro.2020.03.065.

16. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis[J]. Clin Chim Acta, 2020, 506: 145-148. DOI: 10.1016/j.cca.2020. 03.022.

17. Henry BM, De Oliveira MH, Benoit S, et al. Hematologic, biochemical and immune biomarker abnor-malities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a me-ta-analysis[J]. Clin Chem Lab Med, 2020, 58(7): 1021-1028. DOI: 10.1515/cclm-2020-0369.

18. Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in pa-tients with severe coronavirus disease 2019 (COVID-19): a meta-analysis[J]. J Med Virol, 2020. DOI: 10.1002/jmv.25819.

19. Lippi G, Favaloro EJ. D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis[J]. Thromb Haemost, 2020, 120(5): 876-878. DOI: 10.1055/s-0040-1709650.

20. Zhu J, Zhong Z, Li H, et al. CT imaging features of 4121 patients with COVID-19: a meta-analysis[J]. J Med Virol, 2020, 92(7): 891-902. DOI: 10.1002/jmv.25910.

21. Bao C, Liu X, Zhang H, et al. Coronavirus disease 2019 (COVID-19) CT findings: a systematic review and meta-analysis[J]. J Am Coll Radiol, 2020, 17(6): 701-709. DOI: 10.1016/j.jacr.2020.03.006.

22. SHopkins C, Surda P, Kumar N. Presentation of new onset anosmia during the COVID-19 pandemic[J]. Rhinology, 2020, 58(3): 295-298. DOI: 10.4193/Rhin20.116.

23. Patel A, Charani E, Ariyanayagam D, et al. New onset anosmia and ageusia in adult patients diagnosed with SARS-CoV-2[J]. Clin Microbiol Infect, 2020, 26(9): 1236-1241. DOI: 10.1016/j.cmi.2020.05.026.

24. Bagheri SH, Asghari AM, Farhadi M, et al. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak[J]. Med J Islam Repub Iran, 2020, 34: 62. DOI: 10.1101/2020.03.23.20041889.

25. Paderno A, Schreiber A, Grammatica A, et al. Smell and taste alterations in Covid-19: a cross-sectional analysis of different cohorts[J]. Int Forum Allergy Rhinol, 2020, 26(9): 1236-1241. DOI: 10.1002/alr.22610.

26. Boscolo-Rizzo P, Borsetto D, Spinato G, et al. New onset of loss of smell or taste in household contacts of home-isolated SARS-CoV-2-positive subjects[J]. Eur Arch Otorhinolaryngol, 2020: 1-4. DOI: 10.1007/s00405-020-06066-9.

27. Beltrán-Corbellini Á, Chico-García JL, Martínez-Poles J, et al. Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study[J]. Eur J Neurol, 2020, 27(9): 1738-1741. DOI: 10.1111/ene.14273.

28. Wee LE, Chan YF, Teo NW, et al. The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19[J]. Eur Arch Otorhinolaryngol, 2020, 277(8): 2389-2390. DOI: 10.1007/s00405-020-05999-5.

29. Lechien JR, Chiesa-Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study[J]. Eur Arch Otorhinolaryngol, 2020, 277(8): 2251-2261 DOI: 10.1007/s00405-020-05965-1.

30. Luers JC, Rokohl AC, Loreck N, et al. Olfactory and gustatory dysfunction in coronavirus disease 19 (COVID-19)[J]. Clin Infect Dis, 2020, 71(16): 2262-2264. DOI: 10.1093/cid/ciaa525.

31. Spinato G, Fabbris C, Polesel J, et al. Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection[J]. JAMA, 2020, 323(20): 2089-2090. DOI: 10.1001/jama.2020.6771.

32. Moein ST, Hashemian SMR, Mansourafshar B, et al. Smell dysfunction: a biomarker for COVID-19[J]. Int Forum Allergy Rhinol, 2020, 10(8): 944-950. DOI: 10.1002/alr. 22587.

33. Lee Y, Min P, Lee S, et al. Prevalence and duration of acute loss of smell or taste in COVID-19 patients[J]. J Korean Med Sci, 2020, 35(18): e174. DOI: 10.3346/jkms.2020.35.e174.

34. Yan CH, Faraji F, Prajapati DP, et al. Self-reported olfactory loss associates with outpatient clinical course in COVID-19[J]. Int Forum Allergy Rhinol, 2020, 10(7): 821-831. DOI: 10.1002/alr.22592.

35. Xydakis MS, Dehgani-Mobaraki P, Holbrook EH, et al. Smell and taste dysfunction in patients with COVID-19[J]. Lancet Infect Dis, 2020, 20(9): 1015-1016. DOI: 10.1016/s1473-3099(20)30293-0.

36. Gelardi M, Trecca E, Cassano M, et al. Smell and taste dysfunction during the COVID-19 outbreak: a preliminary report[J]. Acta Biomed, 2020, 91(2): 230-231. DOI: 10. 23750/abm.v91i2.9524.

37. Sierpiński R, Pinkas J, Jankowski M, et al. Gender differences in the frequency of gastrointestinal symptoms and olfactory or taste disorders among 1942 non-hospitalized patients with COVID-19[J]. Pol Arch Intern Med, 2020, 40(3): 447-450. DOI: 10.20452/pamw.15414.

38. Lechien JR, Chiesa-Estomba CM, Hans S, et al. Loss of smell and taste in 2013 European patients with mild to moderate COVID-19[J]. Ann Intern Med, 2020, 173(8): 672-675. DOI: 10.7326/m20-2428.

39. Lechien JR, Chiesa-Estomba CM, Place S, et al. Clinical and epidemiological characteristics of 1420 Eu-ropean patients with mild-to-moderate coronavirus disease 2019[J]. J Intern Med, 2020, 288(3): 335-344. DOI: 10. 1111/joim.13089.

40. Hjelmesæth J, Skaare D. Loss of smell or taste as the only symptom of COVID-19[J]. Tidsskr Nor Lae-geforen, 2020, 140(7). DOI: 10.4045/tidsskr.20.0287.

41. Jang Y, Son HJ, Lee S, et al. Olfactory and taste disorder: the first and only sign in a patient with SARS-CoV-2 pneumonia[J]. Infect Control Hosp Epidemiol, 2020, 41(9): 1103. DOI: 10.1017/ice.2020.151.

42. Speth MM, Singer-Cornelius T, Obere M, et al. Olfactory dysfunction and sinonasal symptomatology in COVID-19: prevalence, severity, timing, and associated characteristics[J]. Otolaryngol Head Neck Surg, 2020, 163(1): 114-120. DOI: 10.1177/0194599820929185.

43. Suzuki M, Saito K, Min WP, et al. Identification of viruses in patients with postviral olfactory dysfunc-tion[J]. Laryngoscope, 2007, 117(2): 272-277. DOI: 10.1097/01.mlg.0000249922.37381.1e.

44. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor[J]. Cell, 2020, 181(2): 271-280.e8. DOI: 10.1016/j.cell. 2020.02.052.

45. Giacomelli A, Pezzati L, Conti F, et al. Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study[J]. Clin Infect Dis, 2020, 71(15): 889-890. DOI: 10.1093/cid/ciaa330.

46. Abalo-Lojo JM, Pouso-Diz JM, Gonzalez F. Taste and smell dysfunction in COVID-19 patients[J]. Ann Otol Rhinol Laryngol, 2020, 129(10): 1041-1042. DOI: 10. 1177/0003489420932617.

47. Butowt R, Bilinska K. SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection[J]. ACS Chem Neurosci, 2020, 11(9): 1200-1203. DOI: 10.1021/acschemneuro. 0c00172.

48. Galougahi MK, Ghorbani J, Bakhshayeshkaram M, et al. Olfactory bulb magnetic resonance imaging in SARS-CoV-2-induced anosmia: the first report[J]. Acad Radiol, 2020, 27(6): 892-893. DOI: 10.1016/j.acra.2020. 04.002.

49. Bilinska K, Jakubowska P, Von Bartheld CS, et al. Expression of the SARS-CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium: identification of cell types and trends with age[J]. ACS Chem Neurosci, 2020, 11(11): 1555-1562. DOI: 10.1021/acschemneuro.0c00210.

50. Ralli M, Di Stadio A, Greco A, et al. Defining the burden of olfactory dysfunction in COVID-19 patients[J]. Eur Rev Med Pharmacol Sci, 2020, 24(7): 3440-3441. DOI: 10.26355/eurrev_202004_20797.

51. Le Bon SD, Horoi M. Is anosmia the price to pay in an immune-induced scorched-earth policy against COVID-19?[J]. Med Hypotheses, 2020, 143: 109881. DOI: 10. 1016/j.mehy.2020.109881.

52. Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China[J]. JAMA Neurol, 2020, 77(6): 1-9. DOI: 10.1001/jamaneurol.2020.1127.

53. Kirschenbaum D, Imbach LL, Ulrich S, et al. Inflammatory olfactory neuropathy in two patients with COVID-19[J]. Lancet, 2020, 396(10245): 166. DOI: 10.1016/s0140-6736(20)31525-7.

54. Schriever VA, Merkonidis C, Gupta N, et al. Treatment of smell loss with systemic methylprednisolone[J]. Rhinology, 2012, 50(3): 284-289. DOI: 10.4193/Rhin11.207.

55. Hummel T, Heilmann S, Hüttenbriuk KB. Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract[J]. Laryngoscope, 2002, 112(11): 2076-2080. DOI: 10.1097/00005537-200211000-00031.

56. Reden J, Lill K, Zahnert T, et al. Olfactory function in patients with postinfectious and posttraumatic smell disorders before and after treatment with vitamin a: a double-blind, placebo-controlled, randomized clinical trial[J]. Laryngoscope, 2012, 122(9): 1906-1909. DOI: 10.1002/lary.23405.

57. Izquierdo-Dominguez A, Rojas-Lechuga MJ, Mullol J, et al. Olfactory dysfunction in the COVID-19 out-break[J]. J Investig Allergol Clin Immunol, 2020, 30(5): 317-326. DOI: 10.18176/jiaci.0567.

58. Harless L, Liang J. Pharmacologic treatment for postviral olfactory dysfunction: a systematic review[J]. Int Forum Allergy Rhinol, 2016, 6(7): 760-767. DOI: 10.1002/alr.21727.

59. Hopkins C, Surda P, Whitehead E, et al. Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study[J]. J Otolaryngol Head Neck Surg, 2020, 49(1): 26. DOI: 10.1186/s40463-020-00423-8.

60. Bocksberger S, Wagner W, Hummel T, et al. Temporary hyposmia in COVID-19 patients[J]. Hno, 2020, 68: 440-443. DOI: 10.1007/s00106-020-00891-4.

61. Otte MS, Eckel HN, Poluschkin L, et al. Olfactory dysfunction in patients after recovering from COVID-19[J]. Acta Otolaryngol, 2020, 140(12): 1032-1035. DOI: 10. 1080/00016489.2020.1811999.

62. Yan CH, Faraji F, Prajapati DP, et al. Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms[J]. Int Forum Allergy Rhinol, 2020, 10(7): 806-813. DOI: 10.1002/alr. 22579.

63. Kaye R, Chang CW, Kazahaya K, et al. COVID-19 anosmia reporting tool: initial findings[J]. Otolaryngol Head Neck Surg, 2020, 163(1): 132-134. DOI: 10. 1177/ 0194599820922992.

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