Postcholecystectomy syndrome (PCS) is a clinical syndrome associated with biliary diseases after cholecystectomy, including abdominal pain, dyspepsia, abdominal distension, diarrhea, biliary tract infection, jaundice and other clinical symptoms. To improve the understanding of PCS and select more targeted treatment methods, this review summarizes the etiology, diagnosis and treatment of this syndrome.

1..Gach T, Bogacki P, Markowska B, et al. Quality of life in patients after laparoscopic cholecystectomy due to gallstone disease - evaluation of long-term postoperative results[J]. Pol Przegl Chir, 2021, 93(0): 19-24. DOI: 10.5604/01.3001.0015.4213.

2..Shabanzadeh DM. The symptomatic outcomes of cholecystectomy for gallstones[J]. J Clin Med, 2023, 12(5): 1897. DOI: 10.3390/jcm12051897.

3..Kurihara H, Bunino FM, Fugazza A, et al. Endosonography-guided versus percutaneous gallbladder drainage versus cholecystectomy in fragile patients with acute cholecystitis-a high-volume center study[J]. Medicina (Kaunas), 2022, 58(11): 1647. DOI: 10.3390/medicina58111647.

4..Zackria R, Lopez RA. Postcholecystectomy Syndrome[EB/OL]. (2022-08-29) [2023-02-01]. https://www.ncbi.nlm.nih.gov/books/NBK539902/.

5..Mahfouz MEM, Altowairqi A D M, Alghamdi H Y, et al. Prevalence and factors associated with post-cholecystectomy syndrome in saudi arabia[J]. Cureus, 2022, 14(12): e32827. DOI: 10.7759/cureus.32827.

6..Barrett M, Asbun HJ, Chien HL, et al. Bile duct injury and morbidity following cholecystectomy: a need for improvement[J]. Surg Endosc, 2018, 32(4): 1683-1688. DOI: 10.1007/s00464-017-5847-8.

7..Boivineau G, Gonzalez JM, Gasmi M, et al. Sphincter of Oddi dysfunction[J]. J Visc Surg, 2022, 159(1s): S16-s21. DOI: 10.1016/j.jviscsurg.2022.01.008.

8..中华医学会外科学分会胆道外科学组, 中国医师协会外科医师分会胆道外科医师委员会. 胆囊切除术后常见并发症的诊断与治疗专家共识(2018版)[J]. 中华消化外科杂志, 2018, 17(4): 325-328. [Biliary surgery group, surgical branch, Chinese Medical Association, Biliary Surgeon Committee, Surgical Branch, Chinese Medical Association. Expert consensus on diagnosis and treatment of common complications after cholecys-tectomy (2018 edition)[J]. Chinese Journal of Digestive Surgery, 2018, 17(4): 325-328.] DOI: 10.3760/cma.j.issn. 1673-9752.2018.04.001.

9..Kumar S, Kurian N, Singh RK, et al. Surgical management of cystic duct stump calculi causing post-cholecystectomy syndrome: a prospective study[J]. J Minim Access Surg, 2022. DOI: 10.4103/jmas.jmas_75_22.

10..吴硕东, 田雨, 苏洋, 等. 胆道疾病与十二指肠乳头周围憩室关系的研究[J]. 外科理论与实践, 2007, 12(4): 342-344. [Wu SD, Tian Y, Su Y, et al. The relationship between duodenal diverticulum in the peri-ampullary reglon and biliary diseases[J]. Journal of Surgery Concepts & Practice, 2007, 12(4): 342-344.] DOI: 10.3969/j.issn.1007-9610.2007.04.013.

11..Kennedy AL, Saccone GT, Mawe GM. Direct neuronal interactions between the duodenum and the sphincter of Oddi[J]. Curr Gastroenterol Rep, 2000, 2(2): 104-111. DOI: 10.1007/s11894-000-0093-x.

12..Schofer JM. Biliary causes of postcholecystectomy syndrome[J]. J Emerg Med, 2010, 39(4): 406-410.  DOI: 10.1016/j.jemermed.2007.11.090.

13..朱明辉, 毛康军, 刘颖斌. 胆囊切除术患者焦虑抑郁情绪现状和影响因素调查研究[J]. 中国现代医生, 2013, 51(2): 20-22. [Zhu MH, Mao KJ, Liu YB. Study on anxiety and depression status and the influential factors in patients with cholecystectomy[J]. China Modern Doctor, 2013, 51(2): 20-22.] DOI: CNKI:SUN:ZDYS.0.2013-02-010.

14..Li YD, Liu BN, Zhao SH, et al. Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea[J]. World J Gastroenterol, 2021, 27(5): 391-403. DOI: 10.3748/wjg.v27.i5.391.

15..祁军安, 江奎, 朱海林, 等. LC术后残余胆囊管冗长与术前行MRCP检查的相关性研究[J]. 肝胆胰外科杂志, 2015, 27(1): 15-17. [Qi JA, Jiang K, Zhu HL, et al. Correlative study on cholecystic duct remnant after the LC and preoperative MRCP examination[J]. Journal of Hepatopancreatobiliary Surgery, 2015, 27(1): 15-17.] DOI: 10.11952/j.issn.1007-1954.2015.01.005.

16..Ney MV, Maluf-Filho F, Sakai P, et al. Echo-endoscopy versus endoscopic retrograde cholangiography for the diagnosis of choledocholithiasis: the influence of the size of the stone and diameter of the common bile duct[J]. Arq Gastroenterol, 2005, 42(4): 239-243. DOI: 10.1590/s0004-28032005000400009.

17..Kang X, Guo X, Chen Z, et al. The incidence and severity of post-ercp pancreatitis in patients receiving standard administration of NSAIDs: a systematic review and meta-analysis[J]. J Gastrointest Surg, 2022, 26(11): 2380-2389. DOI: 10.1007/s11605-022-05399-6.

18..Villavicencio Kim J, Wu GY. Update on sphincter of oddi dysfunction: a review[J]. J Clin Transl Hepatol, 2022, 10(3): 515-521. DOI: 10.14218/JCTH.2021.00167.

19..Haider A, Siddiqa A, Ali N, et al. Biliary sphincter of oddi dysfunction[J]. Case Rep Gastroenterol, 2021, 15(1): 443-449. DOI: 10.1159/000514542.

20..Baillie J. Sphincter of Oddi dysfunction[J]. Curr Gastroenterol Rep, 2010, 12(2): 130-134. DOI: 10.1007/s11894-010-0096-1.

21..Shin Y, Choi D, Lee KG, et al. Association between dietary intake and postlaparoscopic cholecystec-tomic symptoms in patients with gallbladder disease[J]. Korean J Intern Med, 2018, 33(4): 829-836. DOI: 10.3904/kjim.2016.223.

22..竺添雨. 雷贝拉唑、铝镁加混悬液及两药联合对胆囊切除后伴有胆汁反流的胃炎疗效[J]. 中外医学研究, 2016, 14(7): 32-34. [Zhu TY. The efficacy of rabeprazole, magnesium aluminum plus suspension and the combina-tion of the two drugs in the treatment of gastritis with bile reflux after cholecystectomy[J]. Chinese and Foreign Medical Research, 2016, 14(7): 32-34.] DOI: 10.14033/j.cnki.cfmr.2016.7.017.

23..贾茸茸. 米曲菌胰酶片治疗胆囊切除术后消化不良的疗效观察[D]. 太原: 山西医科大学, 2016.

24..Yin Z, Xiao Q, Xu G, et al. Acupuncture for the postcholecystectomy syndrome: a systematic review and meta-analysis[J]. Evid Based Complement Alternat Med, 2020, 2020: 7509481. DOI: 10.1155/2020/7509481.

25..侯晓倩. 针灸联合大柴胡汤加减治疗胆囊切除后综合征临床研究[J]. 辽宁中医药大学学报, 2018, 20(6): 123-125. [Hou XQ. Clinical research on the treatment of post-cholecystectomy syndrome by acupuncture com-bined with dachaihu decoction[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2018, 20(6): 123-125.] DOI: 10.13194/j.issn.1673-842x.2018.06.035.